ReviewBiological chemistry2010
Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.
Review in Biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Distinctive blood and salivary proteomics signatures in Qatari individuals at high risk for cardiovascular disease.Scientific reports · 2025Article
- Remodelling of the tumour microenvironment by the kallikrein-related peptidases.Nature reviews. Cancer · 2022Review
- Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration.Journal of neuropathology and experimental neurology · 2013Article
- Induction of complement C3a receptor responses by kallikrein-related peptidase 14.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Protease-armed bacteria in the skin.Cell and tissue research · 2013Review
- Development and immunochemical evaluation of a novel chicken IgY antibody specific for KLK6.Chemistry Central journal · 2012Article
- Human kallikrein-related peptidase 12 (KLK12) splice variants expression in breast cancer and their clinical impact.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.The American journal of pathology · 2011Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.