ArticleWorld journal of gastroenterology2010
Primary mixed germ cell tumor of the liver with sarcomatous components.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Hepatic carcinosarcoma: a rare and aggressive case with unusual molecular signature!Frontiers in oncology · 2026Article
- Primary immature teratoma in the liver with growing teratoma syndrome and gliomatosis peritonei: a rare case report.Diagnostic pathology · 2022Article
- Rare primary mature teratoma of the liver: A case report.World journal of hepatology · 2021Article
- Primary hepatic mixed germ cell tumor in an adult.Journal of pathology and translational medicine · 2021Article
- Hepatocellular carcinoma: a review of diagnostic challenges for the pathologist.Journal of hepatocellular carcinoma · 2018Review
- Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report.Journal of medical case reports · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germ cell tumor (GCT) of the liver is extremely rare. Here, we describe a case of hepatic mixed GCT with significant sarcomatous components and elevated serum alpha-fetoprotein (AFP) in a 34-year-old man. Histopathologically, the tumor was composed of two GCTs components: yolk sac tumor and immature teratoma. The predominant components of immature teratoma consisted of several types of tissue that represented different germinal layers (endoderm, mesoderm and ectoderm) and showed varying degrees of differentiation with significant sarcomatous components. The yolk sac component showed positivity for AFP and cytokeratin (AE1/AE3). The immature teratoma components showed positivity for varying differentiation markers. Interphase cytogenetic analysis revealed that the yolk sac tumor and immature teratoma were positive for i(12p) and 12p over-representation. In particular, the rhabdomyoblastic components also showed typical i(12p) and 12p overrepresentation. This suggested that sarcomatous components may be associated with dedifferentiation or malignant transformation of certain mesenchymal components within teratoma.
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Registered trials
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