ArticleThe Journal of comparative neurology2010
Postnatal changes in tryptophan hydroxylase and serotonin transporter immunoreactivity in multiple brainstem nuclei of the rat: implications for a sensitive period.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Apnea of prematurity and sudden infant death syndrome.Handbook of clinical neurology · 2022Review
- Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex.Physiological reports · 2021Article
- The serotonergic system and the control of breathing during development.Respiratory physiology & neurobiology · 2019Review
- Mechanisms underlying a critical period of respiratory development in the rat.Respiratory physiology & neurobiology · 2019Review
- Acute and chronic changes in the control of breathing in a rat model of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Pituitary adenylate cyclase-activating polypeptide: Postnatal development in multiple brain stem respiratory-related nuclei in the rat.Respiratory physiology & neurobiology · 2019Article
- Brainstem Steering of Locomotor Activity in the Newborn Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Brainstem catecholaminergic neurones and breathing control during postnatal development in male and female rats.The Journal of physiology · 2018Article
- Effects of neonatal hyperoxia on the critical period of postnatal development of neurochemical expressions in brain stem respiratory-related nuclei in the rat.Physiological reports · 2018Article
- Respiratory dysfunction following neonatal sustained hypoxia exposure during a critical window of brain stem extracellular matrix formation.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons.Brain research · 2017Article
- Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities.The European journal of neuroscience · 2017Article
- Microglia modulate brainstem serotonergic expression following neonatal sustained hypoxia exposure: implications for sudden infant death syndrome.The Journal of physiology · 2016Article
- Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Role of brain-derived neurotrophic factor in the excitatory-inhibitory imbalance during the critical period of postnatal respiratory development in the rat.Physiological reports · 2015Article
- Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates.The Journal of comparative neurology · 2015Article
- Reduced levels of brain-derived neurotrophic factor contribute to synaptic imbalance during the critical period of respiratory development in rats.The European journal of neuroscience · 2014Article
- Postnatal development of glycine receptor subunits α1, α2, α3, and β immunoreactivity in multiple brain stem respiratory-related nuclear groups of the rat.Brain research · 2013Article
- Gender considerations in ventilatory and metabolic development in rats: special emphasis on the critical period.Respiratory physiology & neurobiology · 2013Article
- Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models.The Journal of comparative neurology · 2013Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Previously, we found that the brainstem neuronal network in normal rats undergoes abrupt neurochemical, metabolic, and physiological changes around postnatal days (P) 12-13, a critical period when the animal's response to hypoxia is also the weakest. This has special implications for sudden infant death syndrome (SIDS), insofar as seemingly normal infants succumb to SIDS when exposed to respiratory stressors (e.g., hypoxia) during a narrow postnatal window. Because an abnormal serotonergic system has recently been implicated in SIDS, we conducted a large-scale investigation of the 5-HT-synthesizing enzyme tryptophan hydroxylase (TPH) and serotonin transporter (SERT) with semiquantitative immunohistochemistry in multiple brainstem nuclei of normal rats aged P2-21. We found that 1) TPH and SERT immunoreactivity in neurons of raphé magnus, obscurus, and pallidus and SERT in the neuropil of the pre-Bötzinger complex, nucleus ambiguus, and retrotrapezoid nucleus were high at P2-11 but decreased markedly at P12 and plateaued thereafter until P21; 2) SERT labeling in neurons of the lateral paragigantocellular nucleus (LPGi) and parapyramidal region (pPy) was high at P2-9 but fell significantly at P10, followed by a gradual decline until P21; 3) TPH labeling in neurons of the ventrolateral medullary surface was stable except for a significant fall at P12; and 4) TPH and SERT immunoreactivity in a number of other nuclei was relatively stable from P2 to P21. Thus, multiple brainstem nuclei exhibited a significant decline in TPH and SERT immunoreactivity during the critical period, suggesting that such normal development can contribute to a narrow window of vulnerability in postnatal animals.
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