ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2010
Improved network performance via antagonism: From synthetic rescues to multi-drug combinations.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Understanding Braess' Paradox in power grids.Nature communications · 2022Article
- Extreme Antagonism Arising from Gene-Environment Interactions.Biophysical journal · 2020Article
- Antagonistic Phenomena in Network Dynamics.Annual review of condensed matter physics · 2018Article
- Experimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate.PLoS genetics · 2018Article
- Network Pharmacology-Guided Development of a Novel Integrative Regimen to Prevent Acute Graft-vs.-Host Disease.Frontiers in pharmacology · 2018Article
- Suppressive drug combinations and their potential to combat antibiotic resistance.The Journal of antibiotics · 2017Review
- Breaking the Spell: Combating Multidrug Resistant 'Superbugs'.Frontiers in microbiology · 2016Review
- Sub-optimal phenotypes of double-knockout mutants of Escherichia coli depend on the order of gene deletions.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Article
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
- Mechanistic systems modeling to guide drug discovery and development.Drug discovery today · 2013Review
- Realistic control of network dynamics.Nature communications · 2013Article
- Structural controllability of unidirectional bipartite networks.Scientific reports · 2013Article
- Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance.Antimicrobial agents and chemotherapy · 2011Review
- Dispensability of Escherichia coli's latent pathways.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Network medicine: a network-based approach to human disease.Nature reviews. Genetics · 2011Review
- Network synchronization landscape reveals compensatory structures, quantization, and the positive effect of negative interactions.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes - the exact opposite of what traditional gene therapy would suggest. Predictions go as far as to assert that certain gene knockouts can restore the growth of otherwise nonviable gene-deficient cells. Many questions follow from this discovery: What are the underlying mechanisms? How generalizable is this effect? What are the potential applications? Here, I approach these questions from the perspective of compensatory perturbations on networks. Relations are drawn between such synthetic rescues and naturally occurring cascades of reaction inactivation, as well as their analogs in physical and other biological networks. I specially discuss how rescue interactions can lead to the rational design of antagonistic drug combinations that select against resistance and how they can illuminate medical research on cancer, antibiotics, and metabolic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.