ArticleProteomics2010
Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps.
Article in Proteomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy.Arthritis research & therapy · 2024Article
- Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles.Journal of nanobiotechnology · 2023Article
- Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls.Scientific reports · 2022Article
- Multi-omics approaches for revealing the complexity of cardiovascular disease.Briefings in bioinformatics · 2021Review
- Ischemic Heart Disease Selectively Modifies the Right Atrial Appendage Transcriptome.Frontiers in cardiovascular medicine · 2021Article
- Proteomic Profiling Reveals Roles of Stress Response, CaAlcoholism, clinical and experimental research · 2020Article
- Article
- A code for transcription elongation speed.RNA biology · 2018Article
- Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach.Oncotarget · 2017Article
- Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.PLoS genetics · 2017Article
- Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death.Journal of proteome research · 2016Article
- Systems analysis reveals down-regulation of a network of pro-survival miRNAs drives the apoptotic response in dilated cardiomyopathy.Molecular bioSystems · 2015Article
- PSEA-Quant: a protein set enrichment analysis on label-free and label-based protein quantification data.Journal of proteome research · 2014Article
- A central role for Notch in effector CD8(+) T cell differentiation.Nature immunology · 2014Article
- Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages.BMC genomics · 2014Article
- Proteomics for systems toxicology.Computational and structural biotechnology journal · 2014Review
- Protein sets define disease states and predict in vivo effects of drug treatment.Molecular & cellular proteomics : MCP · 2013Article
- Proteomics: from single molecules to biological pathways.Cardiovascular research · 2013Review
- Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation.BMC cardiovascular disorders · 2013Article
- Systems proteomics for translational network medicine.Circulation. Cardiovascular genetics · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Global protein expression profiling can potentially uncover perturbations associated with common forms of heart disease. We have used shotgun MS/MS to monitor the state of biological systems in cardiac tissue correlating with disease onset, cardiac insufficiency and progression to heart failure in a time-course mouse model of dilated cardiomyopathy. However, interpreting the functional significance of the hundreds of differentially expressed proteins has been challenging. Here, we utilize improved enrichment statistical methods and an extensive collection of functionally related gene sets, gaining a more comprehensive understanding of the progressive alterations associated with functional decline in dilated cardiomyopathy. We visualize the enrichment results as an Enrichment Map, where significant gene sets are grouped based on annotation similarity. This approach vastly simplifies the interpretation of the large number of enriched gene sets found. For pathways of specific interest, such as Apoptosis and the MAPK (mitogen-activated protein kinase) cascade, we performed a more detailed analysis of the underlying signaling network, including experimental validation of expression patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.