ArticleCerebellum (London, England)2011
Neurofilament heavy chain expression reveals a unique parasagittal stripe topography in the mouse cerebellum.
Article in Cerebellum (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Altered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21.Translational psychiatry · 2025Article
- Trisomy 21 Alters Motor Coordination, Vocal Communication, and Cerebellar Circuit Connectivity in the TcMAC21 Mouse.Research square · 2025Article
- Essential new insights into human cerebellar Purkinje cell biology from studies of essential tremor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Purkinje cell microzones mediate distinct kinematics of a single movement.Nature communications · 2023Article
- Single-cell multi-omics sequencing and its applications in studying the nervous system.Biophysics reports · 2022Article
- Article
- Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution.Science (New York, N.Y.) · 2019Article
- Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span.Neurobiology of aging · 2018Article
- An optimized surgical approach for obtaining stable extracellular single-unit recordings from the cerebellum of head-fixed behaving mice.Journal of neuroscience methods · 2016Article
- Cerebellar zonal patterning relies on Purkinje cell neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Postnatal development of cerebellar zones revealed by neurofilament heavy chain protein expression.Frontiers in neuroanatomy · 2013Article
- Wholemount immunohistochemistry for revealing complex brain topography.Journal of visualized experiments : JoVE · 2012Article
- Pattern formation during development of the embryonic cerebellum.Frontiers in neuroanatomy · 2012Article
- Architecture and development of olivocerebellar circuit topography.Frontiers in neural circuits · 2012Article
- Cerebellar zones: history, development, and function.Cerebellum (London, England) · 2011Article
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4 authors.
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Abstract
Despite the general uniformity in cellular composition of the adult cerebellum (Cb), the expression of proteins such as ZebrinII/AldolaseC and the small heat shock protein HSP25 reveal striking patterns of parasagittal Purkinje cell (PC) stripes. Based on differences in the stripe configuration within subsets of lobules, the Cb can be further divided into four anterior-posterior transverse zones: anterior zone (AZ) = lobules I-V, central zone (CZ) = lobules VI-VII, posterior zone (PZ) = lobules VIII and anterior IX, and the nodular zone (NZ) = lobules posterior IX-X. Here we used whole-mount and tissue section immunohistochemistry to show that neurofilament heavy chain (NFH) expression alone divides all lobules of the mouse Cb into a complex series of parasagittal stripes of PCs. We revealed that the striped pattern of NFH in the vermis of the AZ and PZ was complementary to ZebrinII and phospholipase C ß3 (PLCß3), and corresponded to phospholipase C ß4 (PLCß4). In the CZ and NZ the stripe pattern of NFH was complementary to HSP25 and corresponded to PLCß3. The boundaries of the NFH stripes were not always sharply delineated. Instead, a gradual decrease in NFH expression was observed toward the edges of particular stripes, resulting in domains comprised of overlapping expression patterns. Furthermore, the terminal field distributions of mossy and climbing fibers had a complex but consistent topographical alignment with NFH stripes. In summary, NFH expression reveals an exquisite level of Cb stripe complexity that respects the transverse zone divisions and delineates an intricately patterned target field for Cb afferents.
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