Evidence map›Paper›PMID 20127273›Full record

ReviewJournal of thrombosis and thrombolysis2010

Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician.

Anandi Krishnan, Renato D Lopes, John H Alexander, Richard C Becker, Larry B Goldstein

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of thrombosis and thrombolysis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Anandi KrishnanDuke Clinical Research Institute, Duke University Medical Center, Box 3850, 27710, Durham, NC, USA.
Renato D Lopes
John H Alexander
Richard C Becker
Larry B Goldstein
Clinical Research Institute · USDuke University Hospital · USDuke Medical Center · US

Funding

SURFACE ENGINEERING IN CONTACT ACTIVATION OF COAGULATIONR01HL069965 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SIEDLECKI, CHRISTOPHER A · 2002 to 2014
$4.1M
Sympathetic and Vascular Function in Sleep ApneaR01HL068699 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LEUENBERGER, URS A · 2003 to 2006
$1.0M
6 · The paper itself

Abstract

Acute ischemic stroke is the result of abrupt interruption of focal cerebral blood flow. The majority of ischemic strokes are caused by embolic or thrombotic arterial occlusions. Acute stroke management is complex, in part because of the varying etiologies of stroke and the very brief window of time for reperfusion therapy. Efforts to optimize stroke care have also encountered barriers including low public awareness of stroke symptoms. As initiatives move forward to improve stroke care worldwide, health care providers and institutions are being called onto deliver the most current evidence-based care. Updated versions of three major guidelines were published in 2008 by the American College of Chest Physicians, the American Heart Association, and the European Stroke Organization. This article presents a concise overview of current recommendations for the use of fibrinolytic therapy for acute ischemic stroke and antithrombotic therapy for secondary prevention. Future directions are also reviewed, with particular emphasis on improving therapeutic options early after stroke onset.

Indexed as

Brain IschemiaFibrinolytic AgentsHumansPhysiciansPractice Guidelines as TopicStrokeFibrinolytic Agents

Identifiers

PMID20127273
OpenAlexW1977229464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.