SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2010
Autologous chondrocyte implantation for the treatment of cartilage lesions of the knee: a systematic review of randomized studies.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- The comparison between the different generations of autologous chondrocyte implantation with other treatment modalities: a systematic review of clinical trials.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Autologous chondrocyte implantation for the treatment of chondral and osteochondral defects of the talus: a meta-analysis of available evidence.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee.The Cochrane database of systematic reviews · 2010Pooled it
- Autologous chondrocyte implantation: a systematic review.The Journal of bone and joint surgery. American volume · 2010Pooled it
- Autologous Osteochondral Transplantation in Large Osteochondral Defects-A Follow-Up of 52 Patients After Knee Joint Resurfacing.Journal of clinical medicine · 2025Article
- The transepicondylar distance is a reliable and easily measured parameter for estimating femoral cartilage surface area using MRI.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Injectable cultured bone marrow derived mesenchymal cells vs chondrocytes in the treatment of chondral defects of the knee - RCT with 6 years follow-up.Journal of clinical orthopaedics and trauma · 2022Article
- Patellar Microfracture: Internal Stabilization House-on-Stilts Technique to Achieve Better Results.Arthroscopy techniques · 2022Article
- Magnetic Hydrogel for Cartilage Tissue Regeneration as well as a Review on Advantages and Disadvantages of Different Cartilage Repair Strategies.BioMed research international · 2022Review
- Effect of the defect localization and size on the success of third-generation autologous chondrocyte implantation in the knee joint.International orthopaedics · 2021Article
- Management of Patellar Chondral Defects with Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures: A Four Years Follow-Up Clinical Trial.Life (Basel, Switzerland) · 2021Article
- Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction.BMC musculoskeletal disorders · 2020Article
- Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of an osteochondral lesion of the ankle.BMJ case reports · 2020Article
- Co-culture of hWJMSCs and pACs in double biomimetic ACECM oriented scaffold enhances mechanical properties and accelerates articular cartilage regeneration in a caprine model.Stem cell research & therapy · 2020Article
- Third-generation autologous chondrocyte implantation after failed bone marrow stimulation leads to inferior clinical results.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Tracking Stem Cell Implants in Cartilage Defects of Minipigs by Using Ferumoxytol-enhanced MRI.Radiology · 2019Article
- Coculture of hWJMSCs and pACs in Oriented Scaffold Enhances Hyaline Cartilage RegenerationStem cells international · 2019Article
- Clinical Tracking of Cell Transfer and Cell Transplantation: Trials and Tribulations.Radiology · 2018Review
- Surgical interventions (microfracture, drilling, mosaicplasty, and allograft transplantation) for treating isolated cartilage defects of the knee in adults.The Cochrane database of systematic reviews · 2016Review
- Avascular necrosis complicating chondral resurfacing techniques.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Autologous chondrocyte implantation (ACI) techniques are becoming more popular for the treatment of full thickness cartilage lesions of the knee joint. However, there is no systematic information for the efficacy of the new generation ACI techniques compared to other treatment options. A systematic review of the existing evidence from randomized clinical trials of ACI treatment would contribute to understanding the advantages and limitations of this method and would inform the planning of future studies. Using pre-defined criteria, we searched a number of electronic databases to identify all the existing randomized control trials of any type of ACI treatment. Risk of bias was assessed and an analysis of the reported outcomes was performed. Information on the clinical efficacy and safety of ACI compared to other interventions was collected and presented. Nine trials were identified with 626 patients. Patients ranged from 15 to 52 years, and the size of treated lesions was between 1 and 22 cm(2). ACI was associated with improvement in clinical outcomes compared to baseline. However, the body of evidence did not suggest any superiority of ACI over other treatments. Complication rates were comparable between interventions except from an increased rate of graft hypertrophies after ACI with periosteum. ACI is an effective treatment for full thickness chondral defects of the knee, providing an improvement of clinical outcomes. However, there is insufficient data to say whether ACI is superior to other treatment strategies. More high quality studies and harmonization in the reported outcomes are needed before specific suggestions for practice can be made.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.