ArticlePloS one2010
TNF-alpha regulates the effects of irradiation in the mouse bone marrow microenvironment.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- The Longitudinal Impact of Radiotherapy on Osseointegrated Hearing Aid Outcomes and Complications.The Laryngoscope · 2025Article
- Preliminary high-dose irradiation of the recipient and associated damage of bone marrow stromal compartment enables bone marrow stroma transplantation.Scientific reports · 2025Article
- CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow.Science advances · 2024Article
- Advances with Platelet-Rich Plasma for Bone Healing.Biologics : targets & therapy · 2024Review
- Imidazolyl Ethanamide Pentandioic Acid (IEPA) as Potential Radical Scavenger during Tumor Therapy in Human Hematopoietic Stem Cells.Molecules (Basel, Switzerland) · 2023Article
- Fractionated Irradiation of Right Thorax Induces Abscopal Damage on Bone Marrow Cells via TNF-α and SAA.International journal of molecular sciences · 2021Article
- Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.Nature communications · 2021Article
- Review
- A Single Radioprotective Dose of Prostaglandin EStem cell reports · 2020Article
- Article
- Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.Nature communications · 2016Article
- Evidence that β7 Integrin Regulates Hematopoietic Stem Cell Homing and Engraftment Through Interaction with MAdCAM-1.Stem cells and development · 2016Article
- Evidence for induction of a tumor metastasis-receptive microenvironment for ovarian cancer cells in bone marrow and other organs as an unwanted and underestimated side effect of chemotherapy/radiotherapy.Journal of ovarian research · 2015Article
- Cytokine expression patterns and mesenchymal stem cell karyotypes from the bone marrow microenvironment of patients with myelodysplastic syndromes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells.Journal of hematology & oncology · 2013Article
- Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity.Journal of radiation research · 2013Article
- Research progress in the mechanism of effect of PRP in bone deficiency healing.TheScientificWorldJournal · 2013Review
- Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice.PloS one · 2013Article
- Irradiated stem cells and ageing of the haematopoietic system.Radiation and environmental biophysics · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecondary bone marrow (BM) myelodysplastic syndromes (MDS) are increasingly common, as a result of radio or chemotherapy administered to a majority of cancer patients. Patients with secondary MDS have increased BM cell apoptosis, which results in BM dysfunction (cytopenias), and an increased risk of developing fatal acute leukemias. In the present study we asked whether TNF-alpha, known to regulate cell apoptosis, could modulate the onset of secondary MDS. PRINCIPAL
findingsWe show that TNF-alpha is induced by irradiation and regulates BM cells apoptosis in vitro and in vivo. In contrast to irradiated wild type (WT) mice, TNF-alpha deficient (TNF-alpha KO) mice or WT mice treated with a TNF-alpha-neutralizing antibody were partially protected from the apoptotic effects of irradiation. Next we established a 3-cycle irradiation protocol, in which mice were sub-lethally irradiated once monthly over a 3 month period. In this model, irradiated WT mice presented loss of microsatellite markers on BM cells, low white blood cell (WBC) counts, reduced megakaryocyte (MK) and platelet levels (thrombocytopenia) and macrocytic anemia, phenoypes that suggest the irradiation protocol resulted in BM dysfunction with clinical features of MDS. In contrast, TNF-alpha KO mice were protected from the irradiation effects: BM cell apoptosis following irradiation was significantly reduced, concomitant with sustained BM MK numbers and absence of other cytopenias. Moreover, irradiated WT mice with long term (> or = 5 months) BM dysfunction had increased BM angiogenesis, MMPs and VEGF and NFkB p65, suggestive of disease progression.
conclusionTaken together, our data shows that TNF-alpha induction following irradiation modulates BM cell apoptosis and is a crucial event in BM dysfunction, secondary MDS onset and progression.
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