ArticlePLoS genetics2010
Genetic crossovers are predicted accurately by the computed human recombination map.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- HAP-SAMPLE2: data-based resampling for association studies with admixture.Bioinformatics (Oxford, England) · 2025Article
- Meiotic chromosome dynamics and double strand break formation in reptiles.Frontiers in cell and developmental biology · 2022Article
- Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.Frontiers in cell and developmental biology · 2021Article
- Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations.Genetics · 2016Article
- Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila.Genome biology and evolution · 2015Article
- DNA recombination. Recombination initiation maps of individual human genomes.Science (New York, N.Y.) · 2014Article
- Article
- Fine-scale mapping of meiotic recombination in Asians.BMC genetics · 2013Article
- Meiotic recombinations within major histocompatibility complex of human embryos.Immunogenetics · 2012Article
- Population demographic history can cause the appearance of recombination hotspots.American journal of human genetics · 2012Article
- Recombination rate variation in closely related species.Heredity · 2011Review
- Similarity in recombination rate estimates highly correlates with genetic differentiation in humans.PloS one · 2011Article
- Isolation of meiotic recombinants from mouse sperm.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis.Journal of molecular evolution · 2010Article
- Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome.Genome biology · 2010Article
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2 authors.
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Abstract
Hotspots of meiotic recombination can change rapidly over time. This instability and the reported high level of inter-individual variation in meiotic recombination puts in question the accuracy of the calculated hotspot map, which is based on the summation of past genetic crossovers. To estimate the accuracy of the computed recombination rate map, we have mapped genetic crossovers to a median resolution of 70 Kb in 10 CEPH pedigrees. We then compared the positions of crossovers with the hotspots computed from HapMap data and performed extensive computer simulations to compare the observed distributions of crossovers with the distributions expected from the calculated recombination rate maps. Here we show that a population-averaged hotspot map computed from linkage disequilibrium data predicts well present-day genetic crossovers. We find that computed hotspot maps accurately estimate both the strength and the position of meiotic hotspots. An in-depth examination of not-predicted crossovers shows that they are preferentially located in regions where hotspots are found in other populations. In summary, we find that by combining several computed population-specific maps we can capture the variation in individual hotspots to generate a hotspot map that can predict almost all present-day genetic crossovers.
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