ArticleTransactions of the American Ophthalmological Society2009
Intraoperative floppy iris syndrome: pathophysiology, prevention, and treatment.
Article in Transactions of the American Ophthalmological Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Comparing the efficacy of mydriatic cocktail-soaked sponge and conventional pupil dilation in patients using tamsulosin - a randomized controlled trial.BMC ophthalmology · 2013Trial
- Surgical considerations in hyperopic cataract patients: optimizing outcomes and reducing complications.Frontiers in medicine · 2025Review
- Relationship Between Tamsulosin Use and Surgical Complications of Cataract Surgery in Elderly Patients: Population-Based Cohort Study.Frontiers in medicine · 2022Article
- Intraoperative floppy iris syndrome: an updated review of literature.International ophthalmology · 2021Review
- A narrative review of intraoperative floppy iris syndrome: an update 2020.Annals of translational medicine · 2020Review
- Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin.Experimental and therapeutic medicine · 2019Article
- The Pharmacological Mydriatic Pupil-to-Limbal Diameter Ratio as an Intuitive Predictor for the Risk of Intraoperative Floppy Iris Syndrome.Journal of ophthalmology · 2018Article
- Anterior Segment Optical Coherence Tomography Analysis of Iris Morphometric Changes Induced by Prostaglandin Analogues Treatment in Patients with Primary Open Angle Glaucoma or Ocular Hypertension.The open ophthalmology journal · 2018Article
- Evaluation of Anterior Segment Changes of Patients Taking Alpha1-Blockers by Ultrasound Biomicroscopy in the Drug-free Period.Turkish journal of ophthalmology · 2017Article
- Effect of tamsulosin on iris vasculature and morphology.Journal of cataract and refractive surgery · 2014Article
- Cataract surgery in patients taking alpha-1 antagonists: know the risks, avoid the complications.Deutsches Arzteblatt international · 2012Review
- [Alpha1-adrenogenic blockers and intraoperative floppy iris syndrome].Atencion primaria · 2012Article
- Complications of cataract surgery in patients with BPH treated with alpha 1A-blockers.Central European journal of urology · 2011Review
- Alfuzosin for the medical treatment of benign prostatic hyperplasia and lower urinary tract symptoms: a systematic review of the literature and narrative synthesis.Therapeutic advances in urologyReview
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Authors and funding
1 author.
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Abstract
purposeTo extend upon previous reports, observations, and discussions of intraoperative floppy iris syndrome (IFIS) with the goal of providing new insight into the syndrome's pathophysiology, prevention, and treatment.
methodsFollowing a review of IFIS and its relationship to autonomic pharmacology, evidence for anatomic changes following exposure of humans and other animals to autonomic drugs is described. The clinical implications for these findings are discussed as they relate to the treatment and prevention of this syndrome.
resultsIFIS has been associated with the use of adrenergic antagonists even after they have been discontinued years prior to surgery. Some investigators believe that this persistence of IFIS reflects anatomic structural change. Evidence from laboratory experiments and human clinical studies using topically applied and systemic autonomic drugs supports the possibility of anatomic changes coexisting with IFIS observed during cataract surgery.
conclusionsIFIS is a relatively rare syndrome, often associated with the use of systemic alpha-blockers and conditions that influence dilator muscle tone. Laboratory and clinical evidence supports the possibility of anatomic changes following the use of autonomic drugs. The persistence of IFIS years after cessation of treatment with alpha-blockers suggests that the potential risks of discontinuing these drugs prior to cataract surgery outweigh potential benefits.
Indexed as
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20126500PMC2814568What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.