ArticleFrontiers in molecular neuroscience2010
Optogenetic deconstruction of sleep-wake circuitry in the brain.
Article in Frontiers in molecular neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state.Nature communications · 2022Article
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Altered sleep intensity upon DBS to hypothalamic sleep-wake centers in rats.Translational neuroscience · 2021Article
- Sleep Deprivation and Neurological Disorders.BioMed research international · 2020Review
- Basal forebrain subcortical projections.Brain structure & function · 2019Article
- Differential Function of Melatonin MTFrontiers in endocrinology · 2019Review
- Hypothalamic Neurons that Regulate Feeding Can Influence Sleep/Wake States Based on Homeostatic Need.Current biology : CB · 2018Article
- Descending projections from the basal forebrain to the orexin neurons in mice.The Journal of comparative neurology · 2017Article
- The Neuropeptide Orexin-A Inhibits the GABAJournal of molecular neuroscience : MN · 2017Article
- Lateral Hypothalamic Control of the Ventral Tegmental Area: Reward Evaluation and the Driving of Motivated Behavior.Frontiers in systems neuroscience · 2017Review
- Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states.F1000Research · 2017Review
- Optogenetic control of human neurons in organotypic brain cultures.Scientific reports · 2016Article
- Optogenetics enlightens neuroscience drug discovery.Nature reviews. Drug discovery · 2016Review
- Optogenetic control of hypocretin (orexin) neurons and arousal circuits.Current topics in behavioral neurosciences · 2015Review
- Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry.Frontiers in systems neuroscience · 2015Review
- What optogenetic stimulation is telling us (and failing to tell us) about fast neurotransmitters and neuromodulators in brain circuits for wake-sleep regulation.Current opinion in neurobiology · 2014Article
- Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A unifying computational framework for stability and flexibility of arousal.Frontiers in systems neuroscience · 2014Article
- Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
How does the brain regulate the sleep-wake cycle? What are the temporal codes of sleep and wake-promoting neural circuits? How do these circuits interact with each other across the light/dark cycle? Over the past few decades, many studies from a variety of disciplines have made substantial progress in answering these fundamental questions. For example, neurobiologists have identified multiple, redundant wake-promoting circuits in the brainstem, hypothalamus, and basal forebrain. Sleep-promoting circuits have been found in the preoptic area and hypothalamus. One of the greatest challenges in recent years has been to selectively record and manipulate these sleep-wake centers in vivo with high spatial and temporal resolution. Recent developments in microbial opsin-based neuromodulation tools, collectively referred to as "optogenetics," have provided a novel method to demonstrate causal links between neural activity and specific behaviors. Here, we propose to use optogenetics as a fundamental tool to probe the necessity, sufficiency, and connectivity of defined neural circuits in the regulation of sleep and wakefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.