ArticlePloS one2010
The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Exploring and validating the necroptotic gene regulation and related lncRNA mechanisms in colon adenocarcinoma based on multi-dimensional data.Scientific reports · 2024Article
- The rationale for development of ligelizumab in food allergy.The World Allergy Organization journal · 2022Review
- Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus.Indian journal of ophthalmology · 2020Review
- Immunoglobulins or Antibodies: IMGTBiomedicines · 2020Review
- IgE Antibodies: From Structure to Function and Clinical Translation.Antibodies (Basel, Switzerland) · 2019Review
- Current Strategies to Inhibit High Affinity FcεRI-Mediated Signaling for the Treatment of Allergic Disease.Frontiers in immunology · 2019Review
- Review
- Review
- Detecting Disease Specific Pathway Substructures through an Integrated Systems Biology Approach.Non-coding RNA · 2017Article
- Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation.Mucosal immunology · 2015Article
- Detection of immunoglobulin isotypes from dried blood spots.Journal of immunological methods · 2014Article
- Inferring drug-disease associations from integration of chemical, genomic and phenotype data using network propagation.BMC medical genomics · 2013Article
- How to connect an IgE-driven response with CTL activity?Cancer immunology, immunotherapy : CII · 2012Article
- Mucosal antibodies in the regulation of tolerance and allergy to foods.Seminars in immunopathology · 2012Review
- Article
- Soluble IgE receptors--elements of the IgE network.Immunology letters · 2011Review
- Heating Affects Structure, Enterocyte Adsorption and Signalling, As Well as Immunogenicity of the Peanut Allergen Ara h 2.The open allergy journal · 2011Article
- Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases.Immunological reviews · 2011Review
- A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum.PloS one · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIgE antibodies play a paramount role in the pathogenesis of various intestinal disorders. To gain insights in IgE-mediated pathophysiology of the gut, we investigated the expression of the high affinity IgE receptor Fc epsilonRI in human intestinal epithelium. METHODOLOGY/PRINCIPAL
findingsFc epsilonRI alpha-chain, as detected by immunohistochemistry, was positive in epithelial cells for eight of eleven (8/11) specimens from colon cancer patients and 5/11 patients with inflammation of the enteric mucosa. The Fc epsilonRIalpha positive epithelial cells co-expressed Fc epsilonRIgamma, whereas with one exception, none of the samples was positive for the beta-chain in the epithelial layer. The functionality of Fc epsilonRI was confirmed in situ by human IgE binding. In experiments with human intestinal tumor cell lines, subconfluent Caco-2/TC7 and HCT-8 cells were found to express the alpha- and gamma-chains of Fc epsilonRI and to bind IgE, whereas confluent cells were negative for gamma-chains. CONCLUSIONS/SIGNIFICANCE: Our data provide the first evidence that the components of a functional Fc epsilonRI are in vitro expressed by the human intestinal epithelial cells depending on differentiation and, more importantly, in situ in epithelia of patients with colon cancer or gastrointestinal inflammations. Thus, a contribution of Fc epsilonRI either to immunosurveillance or pathophysiology of the intestinal epithelium is suggested.
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