ArticleEuropean journal of human genetics : EJHG2010
Common genetic variation and performance on standardized cognitive tests.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.PLoS genetics · 2015Pooled it
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- VNTR Polymorphisms in theBioengineering (Basel, Switzerland) · 2025Article
- The Genetic Architecture of Amygdala Nuclei.Biological psychiatry · 2024Article
- Rare genetic variants correlate with better processing speed.Neurobiology of aging · 2023Article
- Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study.Neurobiology of aging · 2023Article
- Association of low-frequency and rare coding variants with information processing speed.Translational psychiatry · 2021Article
- The morphometry of left cuneus mediating the genetic regulation on working memory.Human brain mapping · 2021Article
- A genome-wide association study of the longitudinal course of executive functions.Translational psychiatry · 2021Article
- Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene.Translational psychiatry · 2021Article
- Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection.Current topics in behavioral neurosciences · 2021Article
- A Unifying Theory for Autism: The Pathogenetic Triad as a Theoretical Framework.Frontiers in psychiatry · 2021Article
- Parental warmth interacts with several genes to affect executive function components: a genome-wide environment interaction study.BMC genetics · 2020Article
- Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.Genes, brain, and behavior · 2019Article
- Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients.BMC psychiatry · 2019Article
- Methylphenidate modifies activity in the prefrontal and parietal cortex accelerating the time judgment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- The BDNF Val66Met Polymorphism Promotes Changes in the Neuronal Integrity and Alters the Time Perception.Journal of molecular neuroscience : MN · 2019Review
- NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly.American journal of human genetics · 2018Article
- Genetic influence alters the brain synchronism in perception and timing.Journal of biomedical science · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One surprising feature of the recently completed waves of genome-wide association studies is the limited impact of common genetic variation in individually detectable polymorphisms on many human traits. This has been particularly pronounced for studies on psychiatric conditions, which have failed to produce clear, replicable associations for common variants. One popular explanation for these negative findings is that many of these traits may be genetically heterogeneous, leading to the idea that relevant endophenotypes may be more genetically tractable. Aspects of cognition may be the most important endophenotypes for psychiatric conditions such as schizophrenia, leading many researchers to pursue large-scale studies on the genetic contributors of cognitive performance in the normal population as a surrogate for aspects of liability to disease. Here, we perform a genome-wide association study with two tests of executive function, Digit Symbol and Stroop Color-Word, in 1086 healthy volunteers and with an expanded cognitive battery in 514 of these volunteers. We show that, consistent with published studies of the psychiatric conditions themselves, no single common variant has a large effect (explaining >4-8% of the population variation) on the performance of healthy individuals on standardized cognitive tests. Given that these are important endophenotypes, our work is consistent with the idea that identifying rare genetic causes of psychiatric conditions may be more important for future research than identifying genetically homogenous endophenotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.