ReviewCurrent opinion in endocrinology, diabetes, and obesity2010
The role of innate immune pathways in type 1 diabetes pathogenesis.
Review in Current opinion in endocrinology, diabetes, and obesity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Advancements and Challenges in Immune Protection Strategies for Islet Transplantation.Journal of diabetes · 2025Review
- Islet transplantation-immunological challenges and current perspectives.World journal of transplantation · 2023Review
- The interplay of galectins-1, -3, and -9 in the immune-inflammatory response underlying cardiovascular and metabolic disease.Cardiovascular diabetology · 2022Review
- Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene-environment associations.Scientific reports · 2022Article
- Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice.Cell host & microbe · 2021Article
- Nasal Methicillin-ResistantMicroorganisms · 2021Article
- The BET family in immunity and disease.Signal transduction and targeted therapy · 2021Review
- Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM.Frontiers in endocrinology · 2020Review
- Enterovirus Neutralizing Antibodies, Monocyte Toll Like Receptors Expression and Interleukin Profiles Are Similar Between Non-affected and Affected Siblings From Long-Term Discordant Type 1 Diabetes Multiplex-Sib Families: The Importance of HLA Background.Frontiers in endocrinology · 2020Article
- Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Innate Immunity Mediated Inflammation and Beta Cell Function: Neighbors or Enemies?Frontiers in endocrinology · 2020Review
- Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.Scientific reports · 2018Article
- Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes.BMC medical genomics · 2017Article
- Positive evidence for vitamin A role in prevention of type 1 diabetes.World journal of diabetes · 2016Review
- Mast cells infiltrate pancreatic islets in human type 1 diabetes.Diabetologia · 2015Article
- Enterovirus and type 1 diabetes: What is the matter?World journal of diabetes · 2015Review
- Alterations in glucose homeostasis in a murine model of Chagas disease.The American journal of pathology · 2013Article
- Influenza A viruses grow in human pancreatic cells and cause pancreatitis and diabetes in an animal model.Journal of virology · 2013Article
- Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Current diabetes reviews · 2013Review
- Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes.Experimental & molecular medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
purpose of reviewType 1 diabetes (T1D) is an autoimmune disease typically believed to result from malfunctions in adaptive immune response signaling which result in activation of self-reactive T cells. However, recent research has indicated components of the innate immune response as having a key role in the initiation of the autoimmune process of T1D. This review will highlight recent studies which examined the role of innate immune response signaling and the connections to T1D pathogenesis. RECENT
findingsInvestigations indicate that components of innate immunity, including inflammation and Toll-like receptor signaling, are involved in pancreatic islet infiltration and insulitis. Recent studies examining the role of viral infections in T1D development also implicate innate immune response signaling in disease pathogenesis. SUMMARY: Current research indicates that components of innate immune response signaling are involved in the initiation of the autoimmune process which results in the eventual destruction of beta cells during T1D pathogenesis. Continuing efforts by researchers to uncover the molecular pathways of innate immunity linked to T1D development could potentially lead to therapeutics capable of preventing and curing the autoimmune disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.