Evidence map›Paper›PMID 20124903›Full record

ArticleEpidemiology (Cambridge, Mass.)2010

Serum dioxin concentrations and time to pregnancy.

Brenda Eskenazi, Marcella Warner, Amy R Marks, Steven Samuels, Larry Needham, Paolo Brambilla, Paolo Mocarelli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Animal models of endocrine disruption.Best practice & research. Clinical endocrinology & metabolism · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Brenda EskenaziSchool of Public Health, University of California at Berkeley, Berkeley, CA 94720-7380, USA. eskenazi@berkeley.edu
Marcella Warner
Amy R Marks
Steven Samuels
Larry Needham
Paolo Brambilla
Paolo Mocarelli
University of California, Berkeley · USBerkeley Public Health Division · USDon Carlo Gnocchi Foundation · ITNational Center for Environmental Health · USUniversity at Albany, State University of New York · USUniversity of Milano-Bicocca · IT

Funding

In Utero Dioxin Exposure in Seveso, Italy and Health of the Second GenerationR01ES007171 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1996 to 2017
$7.1M
ENDOMETRIOSIS AND DIOXIN EXPOSURE OF RESIDENTS OF SEVESOF06TW002075 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1994 to 1994
–
FIC NIH HHS F06 TW002075FIC NIH HHS F06 TW02075-01NIEHS NIH HHS R01 ES007171NIEHS NIH HHS R01 ES07171PHS HHS 2P30-ESO01896-17
6 · The paper itself

Abstract

backgroundPollution may play a role in population trends of declining semen quality and regional differences in time to pregnancy (TTP) in industrialized societies. Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been suspected. In 1976, an explosion near Seveso, Italy resulted in the highest TCDD exposure known in residential populations. Twenty years later, we conducted a retrospective cohort study, the Seveso Women's Health Study.

methodsOf 981 participants, 472 women attempted pregnancy after the explosion, and 278 delivered a livebirth not associated with contraceptive failure. Individual serum TCDD levels were measured from samples collected soon after the explosion and extrapolated to the conception attempt. We examined the relation of TCDD levels to time to pregnancy (parameterized as the monthly probability of conception within the first 12 months of trying) and to infertility (defined as conception after at least 12 months of trying). We modeled fecundability with discrete-time Cox proportional hazards regression, and we modeled fertility with logistic regression. We tested the sensitivity of the conclusions to differing definitions of eligibility and outcome.

resultsMedian TCDD level was 50 parts per trillion, median time to pregnancy was 2 months, and 17% reported taking 12 or more months to conceive. For every 10-fold increase in serum TCDD, we observed a 25% increase in time to pregnancy (adjusted-fecundability odds ratio = 0.75 [95% confidence interval (CI) = 0.60-0.95]) and about a doubling in odds of infertility (adjusted odds ratio = 1.9 [95% CI = 1.1-3.2]). Results were similar for extrapolated TCDD and sensitivity analyses.

conclusionsWe found dose-related increases in TTP and infertility associated with individual serum TCDD levels in the women from Seveso, Italy. These findings may have implications for fertility in industrialized areas.

Indexed as

AdolescentAdultChildChild, PreschoolCohort StudiesConfidence IntervalsFemaleFertilizationHumansInfantInfant, NewbornInfertility, FemaleItalyLogistic ModelsOdds RatioPolychlorinated DibenzodioxinsPolychlorinated Dibenzodioxins

Identifiers

PMID20124903
PMCPMC6267871
OpenAlexW2004863581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.