ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 104 citations in OpenAlex.
- Disruption of GxxxG motifs in pATOM36 impairs biogenesis of the mitochondrial protein translocase of the outer membrane in Trypanosoma brucei.The Journal of biological chemistry · 2026Article
- Mitochondrial Cardiomyopathy: The Roles of mt-tRNA Mutations.Journal of clinical medicine · 2022Review
- How do Chaperones Bind (Partly) Unfolded Client Proteins?Frontiers in molecular biosciences · 2021Review
- Article
- Article
- AnGenes · 2019Article
- Translocase of the Outer Mitochondrial Membrane 40 Is Required for Mitochondrial Biogenesis and Embryo Development inFrontiers in plant science · 2019Article
- A Single Tim Translocase in the Mitosomes of Giardia intestinalis Illustrates Convergence of Protein Import Machines in Anaerobic Eukaryotes.Genome biology and evolution · 2018Article
- Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities.Nucleic acids research · 2018Article
- Origin and Evolutionary Alteration of the Mitochondrial Import System in Eukaryotic Lineages.Molecular biology and evolution · 2017Article
- Biogenesis of a Mitochondrial Outer Membrane Protein inThe Journal of biological chemistry · 2017Article
- Blastocystis Mitochondrial Genomes Appear to Show Multiple Independent Gains and Losses of Start and Stop Codons.Genome biology and evolution · 2016Article
- Lipid synthesis and membrane contact sites: a crossroads for cellular physiology.Journal of lipid research · 2016Review
- Nothing in Evolution Makes Sense Except in the Light of Genomics: Read-Write Genome Evolution as an Active Biological Process.Biology · 2016Review
- Protein import complexes in the mitochondrial outer membrane of Amoebozoa representatives.BMC genomics · 2016Article
- Mitochondrial Dynamics and Heart Failure.Comprehensive Physiology · 2015Review
- Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances.Nature communications · 2015Article
- tRNA biology in mitochondria.International journal of molecular sciences · 2015Review
- A novel Mitosomal β-barrel Outer Membrane Protein in Entamoeba.Scientific reports · 2015Article
- Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.Neurobiology of disease · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All eukaryotes require mitochondria for survival and growth. The origin of mitochondria can be traced down to a single endosymbiotic event between two probably prokaryotic organisms. Subsequent evolution has left mitochondria a collection of heterogeneous organelle variants. Most of these variants have retained their own genome and translation system. In hydrogenosomes and mitosomes, however, the entire genome was lost. All types of mitochondria import most of their proteome from the cytosol, irrespective of whether they have a genome or not. Moreover, in most eukaryotes, a variable number of tRNAs that are required for mitochondrial translation are also imported. Thus, import of macromolecules, both proteins and tRNA, is essential for mitochondrial biogenesis. Here, we review what is known about the evolutionary history of the two processes using a recently revised eukaryotic phylogeny as a framework. We discuss how the processes of protein import and tRNA import relate to each other in an evolutionary context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.