ArticleArchives of general psychiatry2010
Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients.
Article in Archives of general psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Genome-wide association study of suicide attempts in mood disorder patients.The American journal of psychiatry · 2010Pooled it
- Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study.The Journal of clinical psychiatry · 2014Trial
- The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder.Biological psychiatry · 2013Trial
- Electroacupuncture promotes BDNF-dependent neurogenesis via microglial reprogramming in a chronic stress model.Chinese medicine · 2026Article
- Detecting suicide risk in bipolar disorder patients from lymphoblastoid cell lines genetic signatures.Translational psychiatry · 2025Article
- The Influence of Genetic Polymorphisms and Psychosocial Determinants on Suicidal Behaviors: A Case-Control Study ofInternational journal of molecular sciences · 2025Article
- Acupuncture may play a key role in anti-depression through various mechanisms in depression.Chinese medicine · 2024Review
- Stress-Related Roles of Exosomes and Exosomal miRNAs in Common Neuropsychiatric Disorders.International journal of molecular sciences · 2024Review
- Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression inEpigenomics · 2024Article
- Neurotrophin signalling in the human nervous system.Frontiers in molecular neuroscience · 2023Review
- Modeling endophenotypes of suicidal behavior in animals.Neuroscience and biobehavioral reviews · 2021Review
- Genotype-expression interactions for BDNF across human brain regions.BMC genomics · 2021Article
- The mechanism of electroacupuncture for depression on basic research: a systematic review.Chinese medicine · 2021Review
- A major role for common genetic variation in anxiety disorders.Molecular psychiatry · 2020Article
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- The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients.Pharmacological reports : PR · 2020Article
- An Analysis of FiveDisease markers · 2020Article
- Sequence Analysis of Drug Target Genes with Suicidal Behavior in Bipolar Disorder Patients.Molecular neuropsychiatry · 2018Article
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Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
contextA consistent body of evidence supports a role of reduced neurotrophic signaling in the pathophysiology of major depressive disorder (MDD) and suicidal behavior. Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported.
objectiveTo determine whether the brain-derived neurotrophic factor (BDNF) gene or its high-affinity receptor gene, receptor tyrosine kinase 2 (NTRK2), confer risk for suicide attempt (SA) and MDD by investigating common genetic variants in these loci.
designEighty-three tagging single-nucleotide polymorphisms (SNPs) covering the genetic variability of these loci in European populations were assessed in a case-control association design.
settingInpatients and screened control subjects.
participantsThe discovery sample consisted of 394 depressed patients, of whom 113 had SA, and 366 matched healthy control subjects. The replication studies comprised 744 German patients with MDD and 921 African American nonpsychiatric clinic patients, of whom 152 and 119 were positive for SA, respectively.
interventionsBlood or saliva samples were collected from each participant for DNA extraction and genotyping.
main outcome measuresAssociations of SNPs in BDNF and NTRK2 with SA and MDD.
resultsIndependent SNPs within NTRK2 were associated with SA among depressed patients of the discovery sample that could be confirmed in both the German and African American replication samples. Multilocus interaction analysis revealed that single SNP associations within this locus contribute to the risk of SA in a multiplicative and interactive fashion (P = 4.7 x 10(-7) for a 3-SNP model in the combined German sample). The effect size was 4.5 (95% confidence interval, 2.1-9.8) when patients carrying risk genotypes in all 3 markers were compared with those without any of the 3 risk genotypes.
conclusionsOur results suggest that a combination of several independent risk alleles within the NTRK2 locus is associated with SA in depressed patients, further supporting a role of neurotrophins in the pathophysiology of suicide.
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