ArticleThe Journal of cell biology2010
Autonomous right-screw rotation of growth cone filopodia drives neurite turning.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 99 citations in OpenAlex.
- Actin based cell chirality emerging at the boundary of 2D-microtissue directs chiral multicellular pattern formation.Nature communications · 2026Article
- Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton.eLife · 2025Article
- Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.bioRxiv : the preprint server for biology · 2024Article
- Dynamics of multicellular swirling on micropatterned substrates.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An unexpected turn for filopodia.Biophysical journal · 2023Article
- Chiral growth of adherent filopodia.Biophysical journal · 2023Article
- Bending actin filaments: twists of fate.Faculty reviews · 2023Review
- How torque on formins is relaxed strongly affects cellular swirling.Biophysical journal · 2022Article
- Formation of cellular close-ended tunneling nanotubes through mechanical deformation.Science advances · 2022Article
- Filopodia rotate and coil by actively generating twist in their actin shaft.Nature communications · 2022Article
- CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction.Communications biology · 2020Article
- Macropinosome formation by tent pole ruffling in macrophages.The Journal of cell biology · 2018Article
- A tent pole twist on membrane ruffles.The Journal of cell biology · 2018Article
- Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor.Scientific reports · 2018Article
- Cell membrane biophysics with optical tweezers.European biophysics journal : EBJ · 2018Review
- Cell Chirality Drives Left-Right Asymmetric Morphogenesis.Frontiers in cell and developmental biology · 2018Review
- Revealing chiral cell motility by 3D Riesz transform-differential interference contrast microscopy and computational kinematic analysis.Nature communications · 2017Article
- Interference based localization of single emitters.Optics express · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The direction of neurite elongation is controlled by various environmental cues. However, it has been reported that even in the absence of any extrinsic directional signals, neurites turn clockwise on two-dimensional substrates. In this study, we have discovered autonomous rotational motility of the growth cone, which provides a cellular basis for inherent neurite turning. We have developed a technique for monitoring three-dimensional motility of growth cone filopodia and demonstrate that an individual filopodium rotates on its own longitudinal axis in the right-screw direction from the viewpoint of the growth cone body. We also show that the filopodial rotation involves myosins Va and Vb and may be driven by their spiral interactions with filamentous actin. Furthermore, we provide evidence that the unidirectional rotation of filopodia causes deflected neurite elongation, most likely via asymmetric positioning of the filopodia onto the substrate. Although the growth cone itself has been regarded as functionally symmetric, our study reveals the asymmetric nature of growth cone motility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.