ArticleThe Journal of physiology2010
Synchronized bursts of miniature inhibitory postsynaptic currents.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum.The Journal of general physiology · 2023Article
- GABAergic Interneuron and Neurotransmission Are mTOR-Dependently Disturbed in Experimental Focal Cortical Dysplasia.Molecular neurobiology · 2021Article
- Lactation induces increased IPSC bursting in oxytocinergic neurons.Physiological reports · 2019Article
- Short-term potentiation of GABAergic synaptic inputs to vasopressin and oxytocin neurones.The Journal of physiology · 2014Article
- Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Glucocorticoid exerts its non-genomic effect on IPSC by activation of a phospholipase C-dependent pathway in prefrontal cortex of rats.The Journal of physiology · 2013Article
- Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.Journal of neuroendocrinology · 2012Article
- GABA is excitatory in adult vasopressinergic neuroendocrine cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- MMPs and soluble ICAM-5 increase neuronal excitability within in vitro networks of hippocampal neurons.PloS one · 2012Article
- Inhibitory-excitatory synaptic balance is shifted toward increased excitation in magnocellular neurosecretory cells of heart failure rats.Journal of neurophysiology · 2011Article
- Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism.The Journal of physiology · 2011Article
- Depolarising and hyperpolarising actions of GABA(A) receptor activation on gonadotrophin-releasing hormone neurones: towards an emerging consensus.Journal of neuroendocrinology · 2011Review
- Differential regulation of spontaneous and evoked neurotransmitter release at central synapses.Current opinion in neurobiology · 2011Review
- An encounter of the third kind without the usual suspects: coherent activation of asynchronous transmitter release independent of presynaptic excitation.The Journal of physiology · 2010Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Spike-independent miniature postsynaptic currents are generally stochastic and are therefore not thought to mediate information relay in neuronal circuits. However, we recorded endogenous bursts of IPSCs in hypothalamic magnocellular neurones in the presence of TTX, which implicated a coordinated mechanism of spike-independent GABA release. IPSC bursts were identical in the absence of TTX, although the burst incidence increased 5-fold, indicating that IPSC bursts were composed of miniature IPSCs (mIPSCs), and that the probability of burst generation increased with action potential activity. IPSC bursts required extracellular calcium, although they were not dependent on calcium influx through voltage-gated calcium channels or on calcium mobilization from intracellular stores. Current injections simulating IPSC bursts were capable of triggering and terminating action potential trains. In 25% of dual recordings, a subset of IPSC bursts were highly synchronized in onset in pairs of magnocellular neurones. Synchronized IPSC bursts displayed properties that were consistent with simultaneous release at GABA synapses shared between pairs of postsynaptic magnocellular neurones. Synchronized bursts of inhibitory synaptic inputs represent a novel mechanism that may contribute to the action potential burst generation, termination and synchronization responsible for pulsatile hormone release from neuroendocrine cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.