ReviewPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2010
Biophysics and systems biology.
Review in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 138 citations in OpenAlex.
- Mind Everywhere: A Framework for Conceptualizing Goal-Directedness in Biology and Other Domains-Part One.Biological theory · 2026Article
- An in vitro neurobacterial interface reveals direct modulation of neuronal function by gut bacteria.Scientific reports · 2025Article
- Biotechnology systems engineering: preparing the next generation of bioengineers.Frontiers in systems biology · 2025Article
- Fractal Analysis in Clinical Neurosciences: An Overview.Advances in neurobiology · 2024Review
- Is Cancer Reversible? Rethinking Carcinogenesis Models-A New Epistemological Tool.Biomolecules · 2023Review
- Assessing complexity and dynamics in epidemics: geographical barriers and facilitators of foot-and-mouth disease dissemination.Frontiers in veterinary science · 2023Article
- Phenomics as an approach to Comparative Developmental Physiology.Frontiers in physiology · 2023Article
- Biology, Buddhism, and AI: Care as the Driver of Intelligence.Entropy (Basel, Switzerland) · 2022Article
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds.Frontiers in systems neuroscience · 2022Article
- Emergence of informative higher scales in biological systems: a computational toolkit for optimal prediction and control.Communicative & integrative biology · 2020Article
- Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications.PLoS computational biology · 2020Article
- Systems biology of eukaryotic superorganisms and the holobiont concept.Theory in biosciences = Theorie in den Biowissenschaften · 2018Article
- Why an extended evolutionary synthesis is necessary.Interface focus · 2017Review
- Revisiting the Quantum Brain Hypothesis: Toward Quantum (Neuro)biology?Frontiers in molecular neuroscience · 2017Article
- Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases.Frontiers in immunology · 2017Review
- The Nature of Self-Regulatory Fatigue and "Ego Depletion": Lessons From Physical Fatigue.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2016Article
- Preventing Data Ambiguity in Infectious Diseases with Four-Dimensional and Personalized Evaluations.PloS one · 2016Article
- Article
- Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?BioMed research international · 2014Review
- Randomness and multilevel interactions in biology.Theory in biosciences = Theorie in den Biowissenschaften · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded rapidly during the first decade of the twenty-first century and, through its contribution to what is now called systems biology, it is set to revise many of the fundamental principles of biology, including the relations between genotypes and phenotypes. Evolutionary theory, in particular, will require re-assessment. To succeed in this, computational and systems biology will need to develop the theoretical framework required to deal with multilevel interactions. While computational power is necessary, and is forthcoming, it is not sufficient. We will also require mathematical insight, perhaps of a nature we have not yet identified. This article is therefore also a challenge to mathematicians to develop such insights.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.