ReviewPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2010
Synthetic mimetics of protein secondary structure domains.
Review in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Computational prediction and validation of specific EmbR binding site on PknH.Synthetic and systems biotechnology · 2021Article
- Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.Organic & biomolecular chemistry · 2019Article
- Conformationally Restricted Peptides from Rice Proteins Elicit Antibodies That Recognize the Corresponding Native Protein in ELISA Assays.Molecules (Basel, Switzerland) · 2018Article
- Helix-Grafted Pleckstrin Homology Domains Suppress HIV-1 Infection of CD4-Positive Cells.Chembiochem : a European journal of chemical biology · 2016Article
- Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells.Scientific reports · 2016Article
- Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics.PloS one · 2016Article
- New linear antiplasmodial peptides related to angiotensin II.Malaria journal · 2015Article
- GLUE that sticks to HIV: a helix-grafted GLUE protein that selectively binds the HIV gp41 N-terminal helical region.Chembiochem : a European journal of chemical biology · 2015Article
- A unique N-terminal sequence in the Carnation Italian ringspot virus p36 replicase-associated protein interacts with the host cell ESCRT-I component Vps23.Journal of virology · 2014Article
- Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.The Journal of biological chemistry · 2014Article
- Rational design of the survivin/CDK4 complex by combining protein-protein docking and molecular dynamics simulations.Journal of molecular modeling · 2013Article
- A spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell culture.PloS one · 2012Article
- Article
- Enzyme inhibition by allosteric capture of an inactive conformation.Journal of molecular biology · 2011Article
- Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions.Journal of the American Chemical Society · 2011Article
- Beyond natural antimicrobial peptides: multimeric peptides and other peptidomimetic approaches.Cellular and molecular life sciences : CMLS · 2011Review
- A novel peptide antagonist of the human growth hormone receptor.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Proteins modulate the majority of all biological functions and are primarily composed of highly organized secondary structural elements such as helices, turns and sheets. Many of these functions are affected by a small number of key protein-protein contacts, often involving one or more of these well-defined structural elements. Given the ubiquitous nature of these protein recognition domains, their mimicry by peptidic and non-peptidic scaffolds has become a major focus of contemporary research. This review examines several key advances in secondary structure mimicry over the past several years, particularly focusing upon scaffolds that show not only promising projection of functional groups, but also a proven effect in biological systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.