ArticleEnvironmental health perspectives2010
Residential traffic exposure, pulse pressure, and C-reactive protein: consistency and contrast among exposure characterization methods.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01231958 (The Boston Puerto Rican Health Study), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).Environmental health perspectives · 2014Pooled it
- Association of oil spill-related volatile organic compound exposure with CVD-related biomarkers in the Gulf Long-term Follow-up Study.Annals of work exposures and health · 2026Article
- The role of individual and regional environment factors on levels of a cardiovascular risk predictor in middle-aged and older Chinese adults.Journal of global health · 2025Article
- Effects of short- and long-term exposures to particulate matter on inflammatory marker levels in the general population.Environmental science and pollution research international · 2019Article
- Roadside Exposure and Inflammation Biomarkers among a Cohort of Traffic Police in Kathmandu, Nepal.International journal of environmental research and public health · 2019Article
- Longitudinal associations of long-term exposure to ultrafine particles with blood pressure and systemic inflammation in Puerto Rican adults.Environmental health : a global access science source · 2018Article
- Long- and Short-term Exposure to Air Pollution and Inflammatory/Hemostatic Markers in Midlife Women.Epidemiology (Cambridge, Mass.) · 2016Article
- Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project.Environmental health perspectives · 2015Article
- Medication type modifies inflammatory response to traffic exposure in a population with type 2 diabetes.Environmental pollution (Barking, Essex : 1987) · 2015Article
- Residential exposure to urban traffic is associated with increased carotid intima-media thickness in children.Journal of environmental and public health · 2015Article
- Residential proximity to major roadways and prevalent hypertension among postmenopausal women: results from the Women's Health Initiative San Diego Cohort.Journal of the American Heart Association · 2014Article
- Associations of short-term particle and noise exposures with markers of cardiovascular and respiratory health among highway maintenance workers.Environmental health perspectives · 2014Article
- Highway proximity associated with cardiovascular disease risk: the influence of individual-level confounders and exposure misclassification.Environmental health : a global access science source · 2013Article
- A community participatory study of cardiovascular health and exposure to near-highway air pollution: study design and methods.Reviews on environmental health · 2013Review
- In-home air filtration for improving cardiovascular health: lessons from a CBPR study in public housing.Progress in community health partnerships : research, education, and action · 2013Article
- Highway proximity associations with blood markers of inflammation: evidence for a role for IL-1β.Journal of toxicology and environmental health. Part A · 2013Article
- Blood pressure changes and chemical constituents of particulate air pollution: results from the healthy volunteer natural relocation (HVNR) study.Environmental health perspectives · 2013Article
- Residential proximity to nearest major roadway and cognitive function in community-dwelling seniors: results from the MOBILIZE Boston Study.Journal of the American Geriatrics Society · 2012Article
- Estimation of ultrafine particle concentrations at near-highway residences using data from local and central monitors.Atmospheric environment (Oxford, England : 1994) · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundTraffic exposure may increase cardiovascular disease (CVD) risk via systemic inflammation and elevated blood pressure, two important clinical markers for managing disease progression.
objectivesWe assessed degree and consistency of association between traffic exposure indicators as predictors of C-reactive protein (CRP) and pulse pressure (PP) in an adult U.S. Puerto Rican population (n = 1,017).
methodsCross-sectional information on health and demographics and blood data was collected. Using multiple linear regression, we tested for associations between CRP, PP, and six traffic exposure indicators including residential proximity to roads with > 20,000 vehicles/day and traffic density [vehicle miles traveled per square mile (VMT/mi2)]. Diabetes and obesity [body mass index (BMI) >or= 30 kg/m2] were tested as effect modifiers.
resultsCRP was positively associated with traffic density in the total population [36% CRP difference with 95% confidence interval (CI) 2.5-81%] for residence within the highest versus lowest VMT/mi2 level. With BMI >or= 30, CRP showed significant positive associations with five of six traffic indices including residence <or= 200 m versus > 200 m of a roadway [22.7% CRP difference (95% CI, 3.15-46.1)] and traffic density in the third highest versus lowest VMT/mi2 level [28.1% difference (95% CI, 1.0-62.6)]. PP was positively associated with residence within <or= 100 m of a roadway for the total population [2.2 mmHg (95% CI, 0.13-4.3 mmHg)] and persons with BMI >or= 30 [3.8 mmHg (95% CI, 0.88-6.8)]. Effect estimates approximately doubled for residence within <or= 200 m of two or more roadways, particularly in persons with diabetes [8.1 mmHg (95% CI, 2.2-14.1)].
conclusionsTraffic exposure at roadway volumes as low as 20,000-40,000 vehicles/day may increase CVD risk through adverse effects on blood pressure and inflammation. Individuals with elevated inflammation profiles, that is, BMI >or= 30, may be more susceptible to the effects of traffic exposure.
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