ReviewEnvironmental health perspectives2010
Cadmium, environmental exposure, and health outcomes.
Review in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 383 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
383 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,131 citations in OpenAlex.
- Environmental cadmium exposure and the risk of kidney stones: a systematic review and dose-response meta-analysis.Frontiers in medicine · 2025Pooled it
- Outbreak of Haff disease caused by crayfish in China: a systematic review.Journal of health, population, and nutrition · 2024Pooled it
- Beyond the Mind-Serum Trace Element Levels in Schizophrenic Patients: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Pooled it
- Cardioprotective effect of hydroalcoholic extract stem bark ofPharmaceutical biology · 2026Article
- Article
- Integrative analysis of cadmium exposure and osteoarthritis: from population evidence to molecular mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Systematic Review and Meta-Analysis on the Association Between Cadmium and Mercury, with Polycystic Ovary Syndrome.Biological trace element research · 2026Review
- Integrative In Silico and Experimental Analysis Reveals MT1A and HSP70 as Components of a Dual Biomarker Axis for Heavy Metal Exposure.Biological trace element research · 2026Article
- Cadmium exposure triggers a functional switch of APP to drive joint degeneration.Molecular medicine (Cambridge, Mass.) · 2026Article
- Study on the Accumulation, Excretion, and Distribution of Cadmium in Mice After Dietary Exposure to Cadmium-Rich Swimming CrabFoods (Basel, Switzerland) · 2026Article
- Article
- Ameliorative effects of Crocin as a potent antioxidant with its spectral characterization against Cadmium chloride-induced hepatotoxicity.Scientific reports · 2026Article
- Cadmium-Induced Structural Destabilization of the Insulin-Zinc Complex Underlies the Paradox of Elevated but Dysfunctional Insulin.Biological trace element research · 2026Article
- Environmental Cadmium Exposure Exacerbates Alzheimer's-like Pathology in a Gut Microbiota-Involved Manner.Toxics · 2026Article
- Heavy Metals in Agriculture: Sources, Industrial Applications, Plant Toxicity, and Remediation Approaches.International journal of molecular sciences · 2026Review
- Molecular mechanisms linking cadmium chloride exposure to ankylosing spondylitis: an integrative network-based study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Urinary metal exposure, systemic inflammation, and advanced cardiovascular-kidney-metabolic syndrome risk in US adults.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Article
- Study on the Effect of Heavy Metal Contamination of Milk on the Coagulation Process.Foods (Basel, Switzerland) · 2026Article
323 more citing papers are in PubMed but not listed here.
Corrections and comments
- Reprinted as
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe provide an update of the issues surrounding health risk assessment of exposure to cadmium in food. DATA SOURCES: We reviewed epidemiologic studies published between 2004 and 2009 concerning the bioavailability of cadmium in food, assessment of exposure, and body burden estimate, along with exposure-related effects in nonoccupationally exposed populations. DATA EXTRACTION AND SYNTHESIS: Bioavailability of ingested cadmium has been confirmed in studies of persons with elevated dietary exposure, and the findings have been strengthened by the substantial amounts of cadmium accumulated in kidneys, eyes, and other tissues and organs of environmentally exposed individuals. We hypothesized that such accumulation results from the efficient absorption and systemic transport of cadmium, employing multiple transporters that are used for the body's acquisition of calcium, iron, zinc, and manganese. Adverse effects of cadmium on kidney and bone have been observed in environmentally exposed populations at frequencies higher than those predicted from models of exposure. Increasing evidence implicates cadmium in the risk of diseases that involve other tissues and organ systems at cadmium concentrations that do not produce effects on bone or renal function.
conclusionsPopulation data raise concerns about the validity of the current safe intake level that uses the kidney as the sole target in assessing the health risk from ingested cadmium. The data also question the validity of incorporating the default 5% absorption rate in the threshold-type risk assessment model, known as the provisional tolerable weekly intake (PTWI), to derive a safe intake level for cadmium.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.