ArticleEnvironmental health perspectives2010
Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Naringenin's Neuroprotective Effect on Diazino-Induced Cerebellar Damage in Male Albino Rats, with Modulation of Acetylcholinesterase.Brain sciences · 2025Article
- Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective.World journal of diabetes · 2021Review
- Diazinon exposure activated transcriptional factors CCAAT-enhancer-binding proteins α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) and induced adipogenesis in 3T3-L1 preadipocytes.Pesticide biochemistry and physiology · 2018Article
- Diazinon and parathion diverge in their effects on development of noradrenergic systems.Brain research bulletin · 2017Article
- The occurrence and risk assessment of five organophosphorus pesticides in river water from Shangyu, China.Environmental monitoring and assessment · 2016Article
- Maternal Exposure to Synthetic Chemicals and Obesity in the Offspring: Recent Findings.Current environmental health reports · 2015Review
- Knowledge, attitude, and practice of Indonesian farmers regarding the use of personal protective equipment against pesticide exposure.Environmental monitoring and assessment · 2015Article
- Environmental endocrine disruption of energy metabolism and cardiovascular risk.Current diabetes reports · 2014Review
- Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione.Toxicology · 2014Article
- Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling.Bioorganic & medicinal chemistry · 2013Article
- Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review.Environmental health perspectives · 2012Review
- Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids.Brain research bulletin · 2011Article
- Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?Reproductive toxicology (Elmsford, N.Y.) · 2011Review
- Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells.Brain research · 2010Article
- Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum.Brain research bulletin · 2010Article
- Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.Brain research · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOrganophosphorus pesticides (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism. OBJECTIVES/
methodsWe administered diazinon (DZN) or parathion (PRT) to rats on postnatal days 14 at doses straddling the threshold for systemic signs of exposure and assessed the effects on hepatic and cardiac cell signaling mediated through the adenylyl cyclase (AC) cascade.
resultsIn the liver, DZN elicited global sensitization, characterized by parallel up-regulation of AC activity itself and of the responses to stimulants acting at beta-adrenergic receptors, glucagon receptors, or G-proteins. The effects intensified over the course from adolescence to adulthood. In contrast, PRT elicited up-regulation in adolescence that waned by adulthood. Superimposed on these general patterns were effects on glucagon receptor coupling to AC and on responses mediated through the Gi inhibitory protein. The effects on the liver were more substantial than those in the heart, which displayed only transient effects of DZN on AC function in adolescence and no significant effects of PRT. Furthermore, the hepatic effects were greater in magnitude than those in a brain region (cerebellum) that shares similar AC cascade elements.
conclusionsThese findings indicate that OPs alter the trajectory of hepatic cell signaling in a manner consistent with the observed emergence of prediabetes-like metabolic dysfunction. Notably, the various OPs differ in their net impact on peripheral AC signaling, making it unlikely that the effects on signaling reflect their shared property as cholinesterase inhibitors.
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