ArticleEnvironmental health perspectives2010
Modification by ALAD of the association between blood lead and blood pressure in the U.S. population: results from the Third National Health and Nutrition Examination Survey.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Effects of the δ-aminolevulinic acid dehydratase polymorphism rs1800435 on blood lead levels: a new systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Commentary on the Risk Assessment of Lead by the Food Safety Commission of Japan.Food safety (Tokyo, Japan) · 2022Article
- Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation.Arhiv za higijenu rada i toksikologiju · 2020Article
- Letter to editor: Blood pressure, hypertension and lead exposure.Environmental health : a global access science source · 2018Article
- Long-Term Effects of Environmental Lead Exposure on Blood Pressure and Plasma Soluble Cell Adhesion Molecules in Young Adults: A Follow-Up Study of a Prospective Cohort in Kosovo.Journal of environmental and public health · 2018Article
- Association between blood lead and blood pressure: a population-based study in Brazilian adults.Environmental health : a global access science source · 2017Article
- Trends and variability in blood lead concentrations among US adults aged 20-64 years and senior citizens aged ≥65 years.Environmental science and pollution research international · 2016Article
- Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting.Journal of occupational and environmental hygiene · 2015Article
- Lead exposure: a summary of global studies and the need for new studies from Saudi Arabia.Disease markers · 2014Review
- Inverse association of intellectual function with very low blood lead but not with manganese exposure in Italian adolescents.Environmental research · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnvironmental lead exposure has been found to be associated with an increased risk of hypertension. Individuals vary greatly in susceptibility to lead toxicity, and genetic susceptibility has often been cited as the probable cause for such variation.
objectiveThe main objective is to determine the role of the aminolevulinic acid dehydratase (ALAD) gene, which encodes the main carrier protein of lead in blood, in the association between lead exposure and blood pressure (BP) and hypertension in the U.S. population.
methodsWe analyzed data from individuals >or= 17 years of age who participated in the Third National Health and Nutrition Examination Survey for whom DNA was available (n = 6,016). Multivariable logistic and linear regressions stratified by race/ethnicity were used to examine whether hypertension and BP were associated with ALAD and blood lead levels (BLL).
resultsBLL was associated with systolic BP in non-Hispanic whites and with hypertension and systolic and diastolic BP in non-Hispanic blacks. BLL was not associated with BP outcomes in Mexican Americans. Non-Hispanic white ALAD2 carriers in the highest BLL quartile (3.852.9 microg/dL) had a significantly higher adjusted prevalence odds ratio for hypertension compared with ALAD1 homozygous individuals. We also found a significant interaction between lead concentration and the ALAD2 allele in non-Hispanic whites and non-Hispanic blacks in relation to systolic BP.
conclusionsBLL may be an important risk factor for hypertension and increased systolic and diastolic BP. These associations may be modified by ALAD genotype.
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