ArticleEnvironmental health perspectives2010
Exposure of the U.S. population to acrylamide in the National Health and Nutrition Examination Survey 2003-2004.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years: A systemic review.PloS one · 2022Pooled it
- Relationship between gestational acrylamide exposure and offspring's growth: a systematic review and meta-analysis of cohort studies.Public health nutrition · 2020Pooled it
- Dietary acrylamide and human cancer: a systematic review of literature.Nutrition and cancer · 2014Pooled it
- Article
- Is Acrylamide a Hidden Threat to Muscle Health? Integrative Evidence From Epidemiological and Mechanistic Investigations.Food science & nutrition · 2026Article
- Associations between internal exposure to acrylamide and sleep health: evidence from NHANES 2013-2016.BMC public health · 2025Article
- Association of acrylamide exposure with markers of systemic inflammation and serum alpha-klotho concentrations in middle-late adulthood.Frontiers in public health · 2025Article
- Reconstructing population exposures to acrylamide from human monitoring data using a pharmacokinetic framework.Chemosphere · 2023Article
- Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies.Toxics · 2022Article
- Article
- Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females.Environmental science and pollution research international · 2022Article
- The association between biomarkers of acrylamide and cancer mortality in U.S. adult population: Evidence from NHANES 2003-2014.Frontiers in oncology · 2022Article
- Association between acrylamide exposure and the odds of developmental disabilities in children: A cross-sectional study.Frontiers in public health · 2022Article
- Article
- Nicotine and Toxicant Exposure Among Concurrent Users (Co-Users) of Tobacco and Cannabis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes.JAMA network open · 2018Article
- Exposure assessment of process-related contaminants in food by biomarker monitoring.Archives of toxicology · 2018Review
- Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort.International journal of cancer · 2016Article
- Acrylamide and Glycidamide Hemoglobin Adducts and Epithelial Ovarian Cancer: A Nested Case-Control Study in Nonsmoking Postmenopausal Women from the EPIC Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Differences in micronucleus frequency and acrylamide adduct levels with hemoglobin between vegetarians and non-vegetarians.European journal of nutrition · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe lifelong exposure of the population to acrylamide has raised concerns about the possible health effects of the chemical. Data on the extent of exposure to acrylamide and its primary metabolite, glycidamide, are needed to aid in the assessment of potential health effects.
objectivesThe aim of this study was to assess human exposure to acrylamide and glycidamide in the general U.S. population through the measurement of hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA).
methodsHbAA and HbGA were measured in 7,166 subjects from the National Health and Nutrition Examination Survey. Stratified HbAA and HbGA data were reported by sex, age groups, race/ethnicity (Mexican American, non-Hispanic black, non-Hispanic white), and smoking status based on serum cotinine levels. Covariate-adjusted geometric means for each demographic group were calculated using multiple regression analysis.
resultsHbAA and HbGA levels ranged from 3 to 910 and from 4 to 756 pmol/g hemoglobin, respectively, with smokers having the highest levels overall. Tobacco smoke exposure in nonsmokers had a small but significant effect on HbAA and HbGA levels. Adjusted geometric mean levels for children 311 years of age were higher than for adults >or= 60 years of age [mean (95% confidence interval): HbAA, 54.5 (49.1-51.5) and HbGA, 73.9 (71.3-76.6) vs. HbAA, 46.2 (44.3-48.2) and HbGA, 41.8 (38.7-45.2)]. Levels were highest in Mexican Americans [HbAA: 54.8 (51.9-57.8), HbGA: 57.9 (53.7-62.5)], whereas non-Hispanic blacks had the lowest HbGA levels [43.5 (41.1-45.9)].
conclusionsU.S. population levels of acrylamide and glycidamide adducts are described. The high variability among individuals but modest differences between population subgroups suggest that sex, age, and race/ethnicity do not strongly affect acrylamide exposure. Adduct concentration data can be used to estimate relative exposure and to validate intake estimates.
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