Evidence map›Paper›PMID 20123582›Full record

ReviewJournal of the Formosan Medical Association = Taiwan yi zhi2010

Perspectives for preventive and therapeutic HPV vaccines.

Ken Lin, Kimberley Doolan, Chien-Fu Hung, T C Wu

Abstract readReview
In one paragraph

Review in Journal of the Formosan Medical Association = Taiwan yi zhi, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. The vaginal microbiome in HPV persistence and cervical cancer progression.Frontiers in cellular and infection microbiology · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Penile cancer: Updates in systemic therapy.Asian journal of urology · 2022
    Review
  9. Unboxing the molecular modalities of mutagens in cancer.Environmental science and pollution research international · 2022
    Review
  10. Immune-based therapies in penile cancer.Nature reviews. Urology · 2022
    Review
  11. Current and future direction in treatment of HPV-related cervical disease.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Vaccination Strategies for the Control and Treatment of HPV Infection and HPV-Associated Cancer.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2021
    Article
  18. Article
  19. Article
  20. Phase 1 Safety and Immunogenicity Trial of RecombinantMolecular therapy. Methods & clinical development · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ken LinDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Kimberley Doolan
Chien-Fu Hung
T C Wu

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI TZYY-CHOOU WU · 2003 to 2026
$53.5M
ENHANCING HPV-16 E6-SPECIFIC ANTITUMOR IMMUNITYR01CA114425 · NCI · JOHNS HOPKINS UNIVERSITY · PI WU, TZYY-CHOOU · 2005 to 2016
$3.0M
Mechanisms of Papillomavirus NeutralizationR01CA118790 · NCI · JOHNS HOPKINS UNIVERSITY · PI RODEN, RICHARD BRUCE · 2007 to 2018
$2.9M
NCI NIH HHS 1R01 CA114425-01NCI NIH HHS 1R01 CA118790NCI NIH HHS P50 CA098252NCI NIH HHS R01 CA114425NCI NIH HHS R01 CA118790
6 · The paper itself

Abstract

Human Papillomavirus (HPV) has been associated with several human cancers, including cervical cancer, vulvar cancer, vaginal and anal cancer, and a subset of head and neck cancers. Thus effective vaccination against HPV provides an opportunity to reduce the morbidity and mortality associated with HPV. The Food and Drug Administration of the United States has approved two preventive vaccines to limit the spread of HPV. However, these are unlikely to impact upon HPV prevalence and cervical cancer rates for many years. Furthermore, preventive vaccines do not exert therapeutic effects on pre-existing HPV infections and HPV-associated lesions. In order to further impact upon the burden of HPV infections worldwide, therapeutic vaccines are being developed. These vaccines aim to generate a cell-mediated immune response to infected cells. This review discusses current preventive and therapeutic HPV vaccines and their future directions.

Indexed as

Cancer VaccinesFemaleHumansPapillomavirus InfectionsPapillomavirus VaccinesTreatment OutcomeUterine Cervical NeoplasmsVaccinationViral VaccinesCancer VaccinesPapillomavirus VaccinesViral Vaccines

Identifiers

PMID20123582
PMCPMC2908016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.