Evidence map›Paper›PMID 20123271›Full record

ReviewSeminars in pediatric surgery2010

Innovative parenteral and enteral nutrition therapy for intestinal failure.

Hau D Le, Erica M Fallon, Vincent E de Meijer, Alpin D Malkan, Mark Puder, Kathleen M Gura

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in pediatric surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Updates in Intestinal Failure Management.Journal of clinical medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hau D LeDepartment of Surgery, Vascular Biology Program, Children's Hospital Boston, Boston, Massachusetts, USA.
Erica M Fallon
Vincent E de Meijer
Alpin D Malkan
Mark Puder
Kathleen M Gura
Boston Children's Hospital · US

Funding

Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil R01FD003460 · FDA · BOSTON CHILDREN'S HOSPITAL · PI PUDER, MARK · 2008 to 2010
$802k
Mechanisms of Hepatic Steatosis PreventionK08DK069621 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI PUDER, MARK · 2005 to 2009
$639k
Cholestasis Prevention: Efficacy of IV Fish OilR01FD003436 · FDA · BOSTON CHILDREN'S HOSPITAL · PI PUDER, MARK · 2008 to 2009
$359k
FDA HHS 1 R01 FD003436-02FDA HHS 1 R01 FD003460-01NIDDK NIH HHS DK069621-04NIDDK NIH HHS K08 DK069621
6 · The paper itself

Abstract

Children with intestinal failure (IF) suffer from insufficient intestinal length or function, making them dependent on parenteral nutrition (PN) for growth and survival. PN and its components are associated with many complications ranging from simple electrolyte abnormalities to life-threatening PN-associated liver disease, which is also called intestinal failure-associated liver disease (IFALD). From a nutrition perspective, the ultimate goal is to provide adequate caloric requirements and make the transition from PN to full enteral nutrition (EN) successful. Upon review of the literature, we have summarized the most effective and innovative PN and EN therapies for this patient population. Antibiotic-coated catheters and antibiotic or ethanol locks can be implemented, as they appear effective in reducing catheter-related infection and thus further reduce the risk of IFALD. Lipid emulsions should be given judiciously. The use of an omega-3 fatty acid-based formulation should be considered in patients who develop IFALD. Trophic feeding is important for intestinal adaptation, and EN should be initiated early to help wean patients from PN. Long-term management of children with IF continues to be an emerging field. We have entered uncharted territory as more children survive complications of IF and IFALD. Careful monitoring and individualized management to ensure maintenance of growth while avoiding complications are the keys to successful patient outcomes.

Indexed as

Recovery of FunctionCatheter-Related InfectionsChildEnteral NutritionFat Emulsions, IntravenousHumansMalabsorption SyndromesParenteral NutritionShort Bowel SyndromeFat Emulsions, Intravenous

Identifiers

PMID20123271
PMCPMC2819138
OpenAlexW2048960955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.