ArticleJournal of vascular and interventional radiology : JVIR2010
Evolution of shear stress, protein expression, and vessel area in an animal model of arterial dilatation in hemodialysis grafts.
Article in Journal of vascular and interventional radiology : JVIR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Development of a Porcine Model of Arteriovenous Fistula Venous Stenosis Treated with Percutaneous Transluminal Angioplasty.Journal of vascular and interventional radiology : JVIR · 2025Article
- Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome.Investigative ophthalmology & visual science · 2023Observational
- Bindarit encapsulated nanoparticles prevent venous neointimal hyperplasia and restenosis in a murine angioplasty model.Translational research : the journal of laboratory and clinical medicine · 2022Article
- Adventitial delivery of nanoparticles encapsulated with 1α, 25-dihydroxyvitamin DScientific reports · 2021Article
- Reduced patency in left-sided arteriovenous grafts in a porcine model.Journal of vascular surgery · 2020Article
- Atorvastatin ReducesJournal of the American Society of Nephrology : JASN · 2020Article
- Effect of sex differences in treatment response to angioplasty in a murine arteriovenous fistula model.American journal of physiology. Renal physiology · 2020Article
- Evaluation of Venous Stenosis Angioplasty in a Murine Arteriovenous Fistula Model.Journal of vascular and interventional radiology : JVIR · 2019Article
- Effect of Electrical Stimulation on Blood Flow Velocity and Vessel Size.Open medicine (Warsaw, Poland) · 2017Article
- Vein graft failure.Journal of vascular surgery · 2015Review
- Impact of weight loss due to sleeve gastrectomy on shear stress of the femoral vein in morbid obesity.Obesity surgery · 2014Article
- Hemodynamic Shear Stress and Endothelial Dysfunction in Hemodialysis Access.The open urology & nephrology journal · 2014Article
- Expression of profibrotic genes in a murine remnant kidney model.Journal of vascular and interventional radiology : JVIR · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate the wall shear stress, protein expression of matrix metalloproteinase (MMP)-2 and MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 and TIMP-2, and vessel area over time in a porcine model for polytetrafluoroethylene (PTFE) hemodialysis grafts. MATERIALS AND
methodsIn 21 pigs, subtotal renal infarction was created, and 28 days later, a PTFE graft was placed to connect the carotid artery to the ipsilateral jugular vein. Phase-contrast magnetic resonance imaging was used to measure blood flow and vessel area at 1, 3, 7, and 14 days after graft placement. Wall shear stress was estimated from the law of Poiseuille. Animals were killed at day 3 (n = 7), day 7 (n = 7), and day 14 (n = 7) and expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined at the grafted and control arteries.
resultsThe mean wall shear stress of the grafted artery was higher than in the control artery at all time points (P < .05). It peaked by day 3 and decreased by days 7-14 as the vessel area nearly doubled. By days 7-14, there was a significant increase in active MMP-2 followed by a significant increase in pro-MMP-9 and active MMP-9 by day 14 (P < .05, grafted artery vs control). TIMP-1 expression peaked by day 7 and then decreased, whereas TIMP-2 expression was decreased at days 7-14.
conclusionsThe wall shear stress of the grafted artery peaks by day 3, with increased MMP-2 activity by days 7-14, followed by increase pro-MMP-9 and active MMP-9 by day 14. In addition, the vessel area nearly doubled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.