ArticleAnalytical biochemistry2010
Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate.
Article in Analytical biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Identification and validation of genes encoding humoral specificity for the chemical allergen toluene diisocyanate.PloS one · 2026Article
- Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria.Science advances · 2023Article
- Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death.American journal of industrial medicine · 2022Article
- Characterizing Adduct Formation of Electrophilic Skin Allergens with Human Serum Albumin and Hemoglobin.Chemical research in toxicology · 2020Article
- Molecular Characterization and Experimental Utility of Monoclonal Antibodies with Specificity for Aliphatic Di- and Polyisocyanates.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2020Article
- IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.The World Allergy Organization journal · 2020Article
- Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?Chemical research in toxicology · 2019Article
- LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.EC pharmacology and toxicology · 2019Article
- Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol.Xenobiotica; the fate of foreign compounds in biological systems · 2018Article
- Reaction products of hexamethylene diisocyanate vapors with "self" molecules in the airways of rabbits exposed via tracheostomy.Xenobiotica; the fate of foreign compounds in biological systems · 2018Article
- Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future.Chemical research in toxicology · 2017Article
- Identification of novel reaction products of methylene-bis-phenylisocyanate ("MDI") with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fraction.Toxicology in vitro : an international journal published in association with BIBRA · 2016Article
- In vitro cleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1.Xenobiotica; the fate of foreign compounds in biological systems · 2016Article
- Immunochemical detection of the occupational allergen, methylene diphenyl diisocyanate (MDI), in situ.Journal of immunological methods · 2016Article
- Glutathione reaction products with a chemical allergen, methylene-diphenyl diisocyanate, stimulate alternative macrophage activation and eosinophilic airway inflammation.Chemical research in toxicology · 2015Article
- Elevated levels of antibodies against xenobiotics in a subgroup of healthy subjects.Journal of applied toxicology : JAT · 2015Article
- Characterization of methylene diphenyl diisocyanate-haptenated human serum albumin and hemoglobin.Analytical biochemistry · 2013Article
- Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure.Chemico-biological interactions · 2013Article
- Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate.Molecular immunology · 2013Article
- Is specific IgE antibody analysis feasible for the diagnosis of methylenediphenyl diisocyanate-induced occupational asthma?International archives of occupational and environmental health · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Diphenylmethane diisocyanate (MDI), the chemical commonly used as a cross-linking agent in commercial polyurethane production, is a well-recognized cause of asthma. Reaction products between MDI and "self" proteins are hypothesized to act as antigens capable of inducing airway inflammation and asthma; however, such MDI antigens remain incompletely understood. We used a variety of analytical methods to characterize the range of MDI-albumin reaction products that form under physiological conditions. Sites of MDI conjugation on antigenic MDI-albumin products, as defined by serum immunoglobulin G (IgG) from MDI-exposed workers, were determined by high-performance liquid chromatography (HPLC) followed by tandem mass spectrometry (MS/MS). The data identified 14 MDI conjugation sites (12 lysines and 2 asparagines) on human albumin and highlight reaction specificity for the second lysine in dilysine (KK) motifs, and this may be a common characteristic of "immune-sensitizing" chemicals. Several of the MDI conjugation sites are not conserved in albumin from other species, and this may suggest species differences in epitope specificity for self protein (albumin)-isocyanate conjugates. The study also describes new applications of contemporary proteomic methodology for characterizing and standardizing MDI-albumin conjugates destined for use in clinical research.
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Registered trials
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