ReviewExperimental gerontology2010
Animal models of mitochondrial DNA transactions in disease and ageing.
Review in Experimental gerontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Trex1 overexpression leads to longer lifespans and fragmented sleep inApplied biological chemistry · 2026Article
- Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy.Molecules (Basel, Switzerland) · 2018Article
- SUV3 helicase is required for correct processing of mitochondrial transcripts.Nucleic acids research · 2015Article
- Selfish Mitochondrial DNA Proliferates and Diversifies in Small, but not Large, Experimental Populations of Caenorhabditis briggsae.Genome biology and evolution · 2015Article
- Evolution of the metazoan mitochondrial replicase.Genome biology and evolution · 2015Article
- Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function.Molecular biology of the cell · 2015Article
- Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.Nucleic acids research · 2014Article
- Invertebrate models for coenzyme q10 deficiency.Molecular syndromology · 2014Article
- Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase.Molecular systems biology · 2014Article
- Can we define maternal age as a genetic disease?Facts, views & vision in ObGyn · 2014Article
- Replicating animal mitochondrial DNA.Genetics and molecular biology · 2013Review
- Muscle-specific overexpression of the catalytic subunit of DNA polymerase γ induces pupal lethality in Drosophila melanogaster.Archives of insect biochemistry and physiology · 2013Article
- Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae.Genetics · 2012Article
- Article
- Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle.Journal of aging research · 2012Article
- Modeling mitochondrial encephalomyopathy in Drosophila.Neurobiology of disease · 2010Review
- Animal Mitochondrial DNA Replication.The EnzymesReview
- Mechanism of transcription initiation by the yeast mitochondrial RNA polymerase.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mitochondrial DNA (mtDNA) transactions, processes that include mtDNA replication, repair, recombination and transcription constitute the initial stages of mitochondrial biogenesis, and are at the core of understanding mitochondrial biology and medicine. All of the protein players are encoded in nuclear genes: some are proteins with well-known functions in the nucleus, others are well-known mitochondrial proteins now ascribed new functions, and still others are newly discovered factors. In this article we review recent advances in the field of mtDNA transactions with a special focus on physiological studies. In particular, we consider the expression of variant proteins, or altered expression of factors involved in these processes in powerful model organisms, such as Drosophila melanogaster and the mouse, which have promoted recognition of the broad relevance of oxidative phosphorylation defects resulting from improper maintenance of mtDNA. Furthermore, the animal models recapitulate many phenotypes related to human ageing and a variety of different diseases, a feature that has enhanced our understanding of, and inspired theories about, the molecular mechanisms of such biological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.