ArticleDevelopmental biology2010
The transcriptional repressor REST/NRSF modulates hedgehog signaling.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- The Dynamic Roles of Repressor Element 1-Silencing Transcription Factor (REST): A Double-Edged Sword in Neural Health and Disease.Molecular neurobiology · 2025Review
- REST Is Not Resting: REST/NRSF in Health and Disease.Biomolecules · 2023Review
- CRISPR single base editing, neuronal disease modelling and functional genomics for genetic variant analysis: pipeline validation using Kleefstra syndrome EHMT1 haploinsufficiency.Stem cell research & therapy · 2022Article
- Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons.Scientific reports · 2017Article
- Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Rest represses maturation within migrating facial branchiomotor neurons.Developmental biology · 2015Article
- NRSF: an angel or a devil in neurogenesis and neurological diseases.Journal of molecular neuroscience : MN · 2015Review
- Rest mutant zebrafish swim erratically and display atypical spatial preferences.Behavioural brain research · 2015Article
- Article
- Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure.Disease models & mechanisms · 2014Article
- The many faces of neuroendocrine differentiation in prostate cancer progression.Frontiers in oncology · 2014Review
- Article
- Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner.BMC biology · 2012Article
- Zebrafish rest regulates developmental gene expression but not neurogenesis.Development (Cambridge, England) · 2012Article
- Ubiquitination and deubiquitination of REST and its roles in cancers.FEBS letters · 2012Review
- Brain selective transgene expression in zebrafish using an NRSE derived motif.Frontiers in neural circuits · 2012Article
- Article
- The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity.Development (Cambridge, England) · 2011Article
- REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions.Cell cycle (Georgetown, Tex.) · 2010Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The spatial and temporal control of gene expression is key to generation of specific cellular fates during development. Studies of the transcriptional repressor REST/NRSF (RE1 Silencing Transcription Factor or Neural Restrictive Silencing Factor) have provided important insight into the role that epigenetic modifications play in differential gene expression. However, the precise function of REST during embryonic development is not well understood. We have discovered a novel interaction between zebrafish Rest and the Hedgehog (Hh) signaling pathway. We observed that Rest knockdown enhances or represses Hh signaling in a context-dependant manner. In wild-type embryos and embryos with elevated Hh signaling, Rest knockdown augments transcription of Hh target genes. Conversely, in contexts where Hh signaling is diminished, Rest knockdown has the opposite effect and Hh target gene expression is further attenuated. Epistatic analysis revealed that Rest interacts with the Hh pathway at a step downstream of Smo. Furthermore, we present evidence implicating the bifunctional, Hh signaling component Gli2a as key to the Rest modulation of the Hh response. The role of Rest as a regulator of Hh signaling has broad implications for many developmental contexts where REST and Hh signaling act.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.