ArticlePain2010
Hypoalgesia related to elevated resting blood pressure is absent in adolescents and young adults with a history of functional abdominal pain.
Article in Pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02198677 (Randomized Trial of Cardiovascular Response to Two Manual Techniques Non-thrust Joint Manipulation of the Cervical Spine in Patients With Non-traumatic Mechanical Neck Pain.), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial of Cardiovascular Response to Two Manual Techniques Non-thrust Joint Manipulation of the Cervical Spine in Patients With Non-traumatic Mechanical Neck Pain.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- An Open Trial of Morning Bright Light Treatment Among US Military Veterans with Chronic Low Back Pain: A Pilot Study.Pain medicine (Malden, Mass.) · 2019Trial
- Trial
- Do Resting Plasma β-Endorphin Levels Predict Responses to Opioid Analgesics?The Clinical journal of pain · 2017Trial
- The Contribution of Differential Opioid Responsiveness to Identification of Opioid Risk in Chronic Pain Patients.The journal of pain · 2015Trial
- Trial
- Suppression of anger and subsequent pain intensity and behavior among chronic low back pain patients: the role of symptom-specific physiological reactivity.Journal of behavioral medicine · 2012Trial
- Hypoalgesia associated with elevated resting blood pressure: evidence for endogenous opioid involvement.Journal of behavioral medicine · 2010Trial
- Commentary: Understanding Somatic Symptoms: From Dualism to Systems, Diagnosis to Dimensions, Clinical Judgement to Clinical Science.Journal of pediatric psychology · 2019Article
- Is Resolution of Chronic Pain Associated With Changes in Blood Pressure-related Hypoalgesia?Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Article
- Expectancy Effects on Conditioned Pain Modulation Are Not Influenced by Naloxone or Morphine.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Article
- Attachment and adjustment in adolescents and young adults with a history of pediatric functional abdominal pain.The Clinical journal of pain · 2015Article
- Chronic pain and cardiovascular stress responses in a general population: the Tromsø Study.Journal of behavioral medicine · 2014Article
- Functional abdominal pain.Current gastroenterology reports · 2010Article
- Functional abdominal pain in childhood and adolescence increases risk for chronic pain in adulthood.Pain · 2010Article
- Resting blood pressure modulates chest pain intensity in patients with acute myocardial infarction.Pain reportsArticle
- Functional abdominal pain in childhood: background studies and recent research trends.Pain research & managementReview
- Hypertension and pain: A state-based framework for cardiovascular-nociceptive coupling.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Elevated resting blood pressure (BP) is hypoalgesic in healthy individuals, but this effect is absent in adults with chronic somatic pain. This study tested whether BP-related hypoalgesia is similarly altered in individuals with a history of chronic visceral pain in childhood. Resting BP was assessed in 94 adolescents and young adults with a known history of childhood functional abdominal pain (FAP) and 55 comparable healthy controls. Responses to an acute heat pain stimulus were then evaluated following exposure to two laboratory stressors. A significant participant type x systolic BP (SBP) interaction (p<.005) revealed that elevated resting SBP was associated with significantly higher heat pain threshold (p<.001) in healthy controls, but was unrelated to pain threshold in the FAP group. A similar pattern was observed for heat pain tolerance, with elevated SBP linked to significantly higher pain tolerance (p<.05) in healthy controls, but unrelated to tolerance in the FAP group. Dysfunction in BP-related hypoalgesia associated with FAP was evident regardless of whether childhood FAP had resolved or still persisted at the time of laboratory testing. Subgroup analyses indicated that BP-related hypoalgesia (in healthy controls) and FAP-linked absence of this hypoalgesia was observed only among females. Result suggest that childhood visceral chronic pain may be associated with relatively long-lasting dysfunction in overlapping systems modulating pain and BP that persists even after FAP resolves. Potential implications for later hypertension risk are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.