ReviewThe Journal of nutritional biochemistry2010
Mouse models for unraveling the importance of diet in colon cancer prevention.
Review in The Journal of nutritional biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Dietary trans fatty acids and risk of colorectal cancer: a systematic review and meta-analysis of observational studies.European journal of nutrition · 2023Pooled it
- Early Markers of Cardiac and Skeletal Muscle Metabolic Derangement in the Apc(min/+) Male Mouse.Cancer reports (Hoboken, N.J.) · 2025Article
- Butyrate facilitates immune clearance of colorectal cancer cells by suppressing STAT1-mediated PD-L1 expression.Clinics (Sao Paulo, Brazil) · 2023Article
- Calorie restriction remodels gut microbiota and suppresses tumorigenesis of colorectal cancer in mice.Experimental and therapeutic medicine · 2023Article
- Unexpected Liver and Kidney Pathology in C57BL/6J Mice Fed a High-fat Diet and Given Azoxymethane to Induce Colon Cancer.Comparative medicine · 2022Article
- Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system.iScience · 2022Review
- Black raspberries attenuate colonic adenoma development inFood frontiers · 2020Article
- Using Mouse andInternational journal of molecular sciences · 2018Review
- Mouse models in the era of large human tumour sequencing studies.Open biology · 2018Review
- Dietary Methyl Donor Depletion Suppresses Intestinal Adenoma Development.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles.Carcinogenesis · 2015Article
- Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities.Protein & cell · 2015Review
- Exercise effects on polyp burden and immune markers in the ApcMin/+ mouse model of intestinal tumorigenesis.International journal of oncology · 2014Article
- Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras.Cancer letters · 2014Article
- Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks.BMC genomics · 2014Article
- Interaction of dietary fatty acids with tumour necrosis factor family cytokines during colon inflammation and cancer.Mediators of inflammation · 2014Review
- Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention.Molecular nutrition & food research · 2013Article
- Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer.Cytokine · 2013Article
- Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice.PloS one · 2013Article
- Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Diet and genetics are both considered important risk determinants for colorectal cancer, a leading cause of death worldwide. Several genetically engineered mouse models have been created, including the ApcMin mouse, to aid in the identification of key cancer related processes and to assist with the characterization of environmental factors, including the diet, which influence risk. Current research using these models provides evidence that several bioactive food components can inhibit genetically predisposed colorectal cancer, while others increase risk. Specifically, calorie restriction or increased exposure to n-3 fatty acids, sulforaphane, chafuroside, curcumin and dibenzoylmethane were reported protective. Total fat, calories and all-trans retinoic acid are associated with an increased risk. Unraveling the importance of specific dietary components in these models is complicated by the basal diet used, the quantity of test components provided and interactions among food components. Newer models are increasingly available to evaluate fundamental cellular processes, including DNA mismatch repair, immune function and inflammation as markers for colon cancer risk. Unfortunately, these models have been used infrequently to examine the influence of specific dietary components. The enhanced use of these models can shed mechanistic insights about the involvement of specific bioactive food and components and energy as determinants of colon cancer risk. However, the use of available mouse models to exactly represent processes important to human gastrointestinal cancers will remain a continued scientific challenge.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.