ArticleThe American journal of pathology1991
Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Role of Barrier Integrity and Dysfunctions in Maintaining the Healthy Gut and Their Health Outcomes.Frontiers in physiology · 2021Review
- 4-protein signature predicting tamoxifen treatment outcome in recurrent breast cancer.Molecular oncology · 2016Article
- Expression changes of cell-cell adhesion-related genes in colorectal tumors.Oncology letters · 2015Article
- The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas.PloS one · 2015Article
- Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment.Acta pharmacologica Sinica · 2011Review
- Hepatic tight junctions: from viral entry to cancer metastasis.World journal of gastroenterology · 2010Article
- Discovering the molecular components of intercellular junctions--a historical view.Cold Spring Harbor perspectives in biology · 2009Review
- Osteoblasts express claudins and tight junction-associated proteins.Histochemistry and cell biology · 2008Article
- Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells.Brain research · 2007Article
- Expression of occludin, a tight-junction-associated protein, in human lung carcinomas.Virchows Archiv : an international journal of pathology · 2004Article
- Expression of occludin, tight-junction-associated protein, in human digestive tract.The American journal of pathology · 1997Article
- Sequential decrease in tight junctions as revealed by 7H6 tight junction-associated protein during rat hepatocarcinogenesis.Japanese journal of cancer research : Gann · 1994Article
- The molecular organization of tight junctions.The Journal of cell biology · 1993Review
- Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.The Journal of cell biology · 1993Article
- Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.The Journal of cell biology · 1992Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cingulin is a 140-kd protein localized on the cytoplasmic face of avian tight junctions. The expression of cingulin in human normal and neoplastic colonic tissue has been investigated with an antiserum against chicken cingulin. Human cingulin shares its apparent molecular mass and localization with avian cingulin. In normal colonic epithelium, villous adenomas, and differentiated adenocarcinomas, cingulin staining is observed in the junctional region of the polarized cells lining the surface, the crypts, and the glandular lumina. In poorly differentiated adenocarcinomas, labeling also is observed at the interface between cancer tissue and stroma, or in clumps of malignant cells, forming a pattern that highlights the presence of small, compressed lumina. The cingulin content of four adenocarcinomas, estimated by immunoblotting and densitometry, was higher than that of the normal tissue (150% to 230%). Cingulin was detected in a metastasis from a colon adenocarcinoma but not in nonepithelial tissues and neoplasias, suggesting that cingulin may be a useful marker in the characterization of colonic and probably other epithelial neoplasias.
Indexed as
Identifiers
2012170PMC1886117W1639755313What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.