ArticleTissue engineering. Part A2010
Cervical tissue engineering using silk scaffolds and human cervical cells.
Article in Tissue engineering. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Oxygen tension and formation of cervical-like tissue in two-dimensional and three-dimensional culture.Tissue engineering. Part A · 2012Trial
- A Framework for Women's Health Engineering Education: Pedagogical Foundations and Practical Implementation.Annals of biomedical engineering · 2026Review
- Review
- Executive summary: Workshop on preterm birth, January 28-29, 2025, co-sponsored by the American College of Obstetricians and Gynecologists and the Eunice Kennedy Shriver National Institute of Child Health and Human Development.Pregnancy (Hoboken, N.J.) · 2025Article
- Strategies in Tissue Regenerative Engineering for the Treatment of Human Infertility.Stem cell reviews and reports · 2025Review
- Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways†.Biology of reproduction · 2025Article
- Multi-cellular engineered living systems to assess reproductive toxicology.Reproductive toxicology (Elmsford, N.Y.) · 2024Review
- A biomechanical assessment of tissue-engineered polymer neo-uteri after orthotopic implantation.F&S science · 2024Article
- A Combination of Physical and Chemical Treatments Is More Effective in The Preparation of Acellular Uterine Scaffolds.Cell journal · 2023Article
- Bioengineering and the cervix: The past, current, and future for addressing preterm birth.Current research in physiology · 2023Review
- Tissue Engineering for Cervical Function in Pregnancy.Current opinion in biomedical engineering · 2022Article
- Partial Reconstruction of Uterus Cervix in Rat by Decellularized Human Uterine Cervical Scaffold Combined with Adipose-Derived Stem Cells (ADSCs).Journal of immunology research · 2022Article
- Review
- Bioengineering of the Uterus.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Regenerative Medicine Approaches in Bioengineering Female Reproductive Tissues.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Cell-based endometrial regeneration: current status and future perspectives.Cell and tissue research · 2021Review
- Combating COVID-19 with tissue engineering: a review.Emergent materials · 2021Review
- Three-Dimensional Biofabrication Models of Endometriosis and the Endometriotic Microenvironment.Biomedicines · 2020Article
- Ex vivo pregnant-like tissue model to assess injectable hydrogel for preterm birth prevention.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Organs-On-Chip Models of the Female Reproductive System.Bioengineering (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Spontaneous preterm birth is a frequent complication of pregnancy and a common cause of morbidity in childhood. Obstetricians suspect abnormalities of the cervix are implicated in a significant number of preterm births. The cervix is composed of fibrous connective tissue and undergoes significant remodeling in preparation for birth. We hypothesized that a tissue engineering strategy could be used to develop three-dimensional cervical-like tissue constructs that would be suitable for investigating cervical remodeling. Cervical cells were isolated from two premenopausal women undergoing hysterectomy for a benign gynecological condition, and the cells were seeded on porous silk scaffolds in the presence or absence of dynamic culture and with 10% or 20% serum. Morphological, biochemical, and mechanical properties were measured during the 8-week culture period. Cervical cells proliferated in three-dimensions and synthesized an extracellular matrix with biochemical constituents and morphology similar to native tissue. Compared to static culture, dynamic culture was associated with significantly increased collagen deposition (p < 0.05), sulfated glycosaminoglycan synthesis (p < 0.05), and mechanical stiffness (p < 0.05). Serum concentration did not affect measured variables. Relevant human tissue-engineered cervical-like constructs constitute a novel model system for a range of fundamental and applied studies related to cervical remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.