ArticleSleep2010
Does narcolepsy symptom severity vary according to HLA-DQB1*0602 allele status?
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- HLA-DQB1*06:02 allele frequency and clinic-polysomnographic features in Saudi Arabian patients with narcolepsy.Sleep & breathing = Schlaf & Atmung · 2019Article
- Genetic Ancestry for Sleep Research: Leveraging Health Inequalities to Identify Causal Genetic Variants.Chest · 2018Review
- Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.PLoS medicine · 2017Article
- Narcolepsy in African Americans.Sleep · 2015Article
- Article
- Sleep disorders in multiple sclerosis. Review.Current neurology and neuroscience reports · 2015Review
- Identification of the variations in the CPT1B and CHKB genes along with the HLA-DQB1*06:02 allele in Turkish narcolepsy patients and healthy persons.Genetic testing and molecular biomarkers · 2014Article
- Narcolepsy in the pediatric population.Current neurology and neuroscience reports · 2012Article
- TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.Sleep medicine · 2012Article
- Use of PCR with sequence-specific primers for high-resolution human leukocyte antigen typing of patients with narcolepsy.Annals of laboratory medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo investigate associations between HLA-DQB1*0602 allele status and measures of narcolepsy symptom severity.
designCross-sectional study of population-based narcolepsy patients.
settingKing County, Washington.
participantsAll prevalent cases (n = 279) of physician-diagnosed narcolepsy ascertained from 2001-2005.
interventionsN/A. MEASUREMENTS: Narcolepsy diagnosis was based on cataplexy status, diagnostic sleep study results, and chart review. The number of HLA-DQB1 alleles was determined from buccal genomic DNA. Symptom severity instruments included the Epworth Sleepiness Scale (ESS), the Ullanlinna Narcolepsy Scale (UNS), age of symptom onset, subjective sleep latency and duration, and various clinical sleep parameters. We used linear regression adjusted for African American race and an extended chi-square test of trend to assess relationships across ordered groups defined by allele number (0, 1, or 2).
resultsNarcolepsy patients were 63% female and 82% Caucasian, with a mean age of 47.6 years (SD = 17.1). One hundred forty-one (51%) patients had no DQB1*0602 alleles; 117 (42%) had one; and 21 (7%) had two. In the complete narcolepsy sample after adjustment for African American race, we observed a linear relationship between HLA-DQB1*0602 frequency and sleepiness as defined by the ESS (P < 0.01), narcolepsy severity as defined by UNS (P < 0.001), age of symptom onset (P < 0.05), and sleep latency (P < 0.001). In univariate analyses, HLA-DQB1*0602 frequency was also associated with napping (P < 0.05) and increased car and work accidents or near accidents (both P < 0.01). Habitual sleep duration was not associated with HLA status. These race-adjusted associations remained for the ESS (P < 0.05), UNS (P < 0.01), and sleep latency (P < 0.001) when restricting to narcolepsy with cataplexy.
conclusionsNarcolepsy symptom severity varies in a linear manner according to HLA-DQB1*0602 allele status. These findings support the notion that HLA-DQ is a disease-modifying gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.