ArticleNatural product communications2009
Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from Twilight Zone waters around Guam.
Article in Natural product communications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Deep-Sea Coral Garden Invertebrates and Their Associated Fungi Are Genetic Resources for Chronic Disease Drug Discovery.Marine drugs · 2021Article
- Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms.Marine drugs · 2021Review
- Discovery of Cymopolyphenols A-F From a Marine Mesophotic ZoneFrontiers in microbiology · 2021Article
- A Chemometric Analysis of Deep-Sea Natural Products.Molecules (Basel, Switzerland) · 2019Article
- Partially Purified Extracts of Sea AnemoneBioMed research international · 2016Article
- Cytotoxic and apoptotic evaluations of marine bacteria isolated from brine-seawater interface of the Red Sea.BMC complementary and alternative medicine · 2013Article
- Twilight zone sponges from Guam yield theonellin isocyanate and psammaplysins I and J.Journal of natural products · 2012Article
- Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Porifera and Coelenterata.World journal of clinical oncology · 2011Article
- Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.Bioorganic & medicinal chemistry · 2011Article
- Bioactive compounds from the fern Lepisorus contortus.Journal of natural products · 2011Article
- Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.Journal of medicinal chemistry · 2010Article
- A partnership between the cancer research center of Hawaii and the University of Guam in Cancer Research, Education, Training, and Outreach.Hawaii medical journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
The cancer chemopreventive and cytotoxic properties of 50 extracts derived from Twilight Zone (50-150 m) sponges, gorgonians and associated bacteria, together with 15 extracts from shallow water hard corals, as well as 16 fractions derived from the methanol solubles of the Twilight Zone sponge Suberea sp, were assessed in a series of bioassays. These assays included: Induction of quinone reductase (QR), inhibition of TNF-alpha activated nuclear factor kappa B (NFkappaB), inhibition of aromatase, interaction with retinoid X receptor (RXR), inhibition of nitric oxide (NO) synthase, inhibition 2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), and inhibition of HL-60 and MCF-7 cell proliferation. The results of these assays showed that at least 10 extracts and five fractions inhibited NFkappaB by greater than 60%, two extracts and two fractions inhibited DPPH by more than 50%, nine extracts and two fractions affected the survival of HL-60 cells, no extracts or fractions affected RXR, three extracts and six fractions affected quinone reductase (QR), three extracts and 12 fractions significantly inhibited aromatase, four extracts and five fractions inhibited nitric oxide synthase, and one extract and no fractions inhibited the growth of MCF-7 cells by more than 95%. These data revealed the tested samples to have many and varied activities, making them, as shown with the extract of the Suberea species, useful starting points for further fractionation and purification. Moreover, the large number of samples demonstrating activity in only one or sometimes two assays accentuates the potential of the Twilight Zone, as a largely unexplored habitat, for the discovery of selectively bioactive compounds. The overall high hit rate in many of the employed assays is considered to be a significant finding in terms of "normal" hit rates associated with similar samples from shallower depths.
Indexed as
Identifiers
20120114PMC2842916W1514788203What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.