ArticleObesity surgery2010
Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass.
Article in Obesity surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Gastric bypass reduces fat intake and preference.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Trial
- Mechanisms of metabolic surgery effectiveness in obesity and type 2 diabetes: a puzzle with some known pieces.International journal of obesity (2005) · 2025Review
- Vagal-Sparing Versus Non-Vagal-Sparing Roux-en-Y Gastric Bypass: Complications and Weight Outcomes.Obesity surgery · 2025Article
- Long-Term Results of Linear Versus Circular Stapled Gastrojejunostomy in Gastric Bypass Surgery: A Propensity Score-Adjusted Analysis of Weight Loss and Morbidity.Obesity surgery · 2025Article
- Novel Insights into the Physiology of Nutrient Sensing and Gut-Brain Communication in Surgical and Experimental Obesity Therapy.Obesity surgery · 2023Review
- GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats.Biomedicines · 2023Article
- Mechanisms of Weight Loss After Obesity Surgery.Endocrine reviews · 2022Review
- Early Postoperative Exposure to High-Fat Diet Does Not Increase Long-Term Weight Loss or Fat Avoidance After Roux-en-Y Gastric Bypass in Rats.Frontiers in nutrition · 2022Article
- The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats.Scientific reports · 2021Article
- The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response.Pharmacology & therapeutics · 2021Review
- Gastric bypass in female rats lowers concentrated sugar solution intake and preference without affecting brief-access licking after long-term sugar exposure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Meal patterns after bariatric surgery in mice and rats.Appetite · 2020Review
- The gut microbiota to the brain axis in the metabolic control.Reviews in endocrine & metabolic disorders · 2019Review
- Optimization of a Technique to Standardize the Rodent Roux-En-Y Gastric Bypass Model and Troubleshooting of Postoperative Failures.Obesity surgery · 2019Article
- Mechanisms for the metabolic success of bariatric surgery.Journal of neuroendocrinology · 2019Review
- Gut vagal sensory signaling regulates hippocampus function through multi-order pathways.Nature communications · 2018Article
- Linear stapled gastrojejunostomy results in fewer strictures compared to circular stapled gastrojejunostomy in laparoscopic gastric bypass surgery.Langenbeck's archives of surgery · 2017Article
- Novel developments in vagal afferent nutrient sensing and its role in energy homeostasis.Current opinion in pharmacology · 2016Review
- Does gastric bypass surgery change body weight set point?International journal of obesity supplements · 2016Review
- Eating in mice with gastric bypass surgery causes exaggerated activation of brainstem anorexia circuit.International journal of obesity (2005) · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome.
methodsBody weight, food intake and postprandial peptide YY (PYY) and glucagon-like peptide (GLP-1) levels were compared between gastric bypass (n = 55) and sham-operated rats (n = 27) in three groups. In group 1 (n = 17), the vagal nerve was not preserved, while in group 2 the vagal nerve was preserved during gastric bypass (n = 10). In group 3, gastric bypass rats (n = 28) were randomised for either one of the two techniques.
resultsRats in which the vagal nerve was preserved during gastric bypass showed a lower body weight (p < 0.001) and reduced food intake (p < 0.001) compared to rats in which the vagal nerve was not preserved during the gastric bypass operation. Levels of PYY and GLP-1 were significantly increased after gastric bypass compared to sham-operated controls (p < 0.05), but there was no difference between gastric bypass rats with and without vagal preservation. Differences in food intake and body weight were not related to the size of the gastro-jejunostomy in gastric bypass rats. There were no signs of malabsorption or inflammation after gastric bypass.
conclusionWe propose that the vagal nerve should be preserved during the gastric bypass operation as this might play an important role for the mechanisms that induce weight loss and reduce food intake in rats. In contrast, the gastro-jejunal stoma size was found to be of minor relevance.
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