ReviewJournal of molecular medicine (Berlin, Germany)2010
The response of the host microcirculation to bacterial sepsis: does the pathogen matter?
Review in Journal of molecular medicine (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Exploring the anti‑inflammatory activity of boron compounds through the miR‑21/PTEN/AKT pathway in cecal ligation and puncture‑induced sepsis.Molecular medicine reports · 2025Article
- Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling.Intensive care medicine · 2023Review
- Posterior Reversible Encephalopathy in Sepsis-Associated Encephalopathy: Experience from a Single Center.Neurocritical care · 2022Observational
- Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock.Interventional medicine & applied science · 2021Article
- Targeting Endothelial Barrier Dysfunction Caused by Circulating Bacterial and Mitochondrial N-Formyl Peptides With Deformylase.Frontiers in immunology · 2019Article
- Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Injured Patients: Which Ratio to Choose to Predict Outcome and Nature of Bacteremia?Mediators of inflammation · 2018Observational
- Impact of Unsaturated Fatty Acids on Cytokine-Driven Endothelial Cell Dysfunction.International journal of molecular sciences · 2017Article
- Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.Lab on a chip · 2016Article
- Cytokine profile in severe Gram-positive and Gram-negative abdominal sepsis.Scientific reports · 2015Article
- Acute inflammatory response in the subcutaneous versus periprosthethic space after incisional hernia repair: an original article.BMC surgery · 2014Article
- Platelet membrane potential: unable to pull the plug on sepsis.Critical care (London, England) · 2014Article
- CD137 expressed on neutrophils plays dual roles in antibacterial responses against Gram-positive and Gram-negative bacterial infections.Infection and immunity · 2013Article
- Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators.Frontiers in physiology · 2013Article
- Lipoteichoic acid induces surfactant protein-A biosynthesis in human alveolar type II epithelial cells through activating the MEK1/2-ERK1/2-NF-κB pathway.Respiratory research · 2012Article
- A microfluidics approach towards high-throughput pathogen removal from blood using margination.Biomicrofluidics · 2012Article
- HMGB1 increases permeability of the endothelial cell monolayer via RAGE and Src family tyrosine kinase pathways.Inflammation · 2012Article
- Article
- Accentuate the (Gram) positive.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Exogenous heat shock protein HSP70 suppresses bacterial pathogen-induced activation of human neutrophils.Doklady. Biochemistry and biophysicsArticle
- Molecular mechanisms of organ damage in sepsis: an overview.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis results from the interaction between a host and an invading pathogen. The microcirculatory dysfunction is now considered central in the development of the often deadly multiple organ dysfunction syndrome in septic shock patients. The microcirculatory flow shutdown and flow shunting leading to oxygen demand and supply mismatch at the cellular level and the local activation of inflammatory pathways resulting from the leukocyte-endothelium interactions are both features of the sepsis-induced microcirculatory dysfunction. Although the host response through the inflammatory and immunologic response appears to be critical, there are also evidences that Gram-positive and Gram-negative bacteria can exert different effects at the microcirculatory level. In this review we discuss available data on the potential bacterial-specific microcirculatory alterations observed during sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.