ArticleJournal of molecular modeling2010
Distinct interactions between the human adrenergic beta(2) receptor and Galpha(s)--an in silico study.
Article in Journal of molecular modeling, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Molecular modeling studies give hint for the existence of a symmetric hβ₂R-Gαβγ-homodimer.Journal of molecular modeling · 2013Article
- hβ2R-Gαs complex: prediction versus crystal structure--how valuable are predictions based on molecular modeling studies?Journal of molecular modeling · 2012Article
- Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH.Journal of molecular biology · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to perform an in silico analysis of the interaction of the human beta(2) adrenergic receptor with Galpha(s). In a first step, a systematic surface-interaction-scan between the inactive or active human beta(2) adrenergic receptor and Galpha(s) was performed in order to gain knowledge about energetically preferred areas on the potential energy surface. Subsequently, two energetically favored regions for the active human beta(2) adrenergic receptor-Galpha(s) complex were identified. Two representative complex structures were put into a POPC (1-palmitoyl-2-oleoyl-phosphatidylcholine) bilayer and solvated in order to perform molecular dynamic simulations. The simulations revealed that both conformations, which have comparable potential energy, are stable. A mean number of about 14 hydrogen bonds was observed between the active receptor and Galpha(s) for both conformations. Based on these results, two energetically favored beta(2)-Galpha(s)complexes can be proposed.
Indexed as
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20119640What OpenQuestion holds
Registered trials
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