ArticleThe Journal of biological chemistry2010
Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Developmental origins of hypertension and renal injury: epigenetic memory in renal stem and progenitor cells.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Diet and Lipidomics Mediated Regulation of Mesenchymal Stem Cell Function: Diet, Omics and Stem Cell Connection.Biomolecules · 2026Review
- Abnormal epigenetic memory of mesenchymal stem and progenitor cells caused by fetal malnutrition induces hypertension and renal injury in adulthood.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine.Frontiers in cell and developmental biology · 2020Review
- Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells.In vitro cellular & developmental biology. Animal · 2019Article
- WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion.Stem cell reports · 2017Article
- The PPAR-gamma-binding sequence Pal3 is necessary for basal but dispensable for high-fat diet regulated human renin expression in the kidney.Pflugers Archiv : European journal of physiology · 2017Article
- Juxtaglomerular Cell Phenotypic Plasticity.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Review
- Human kidney pericytes produce renin.Kidney international · 2016Article
- Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications.Stem cells international · 2016Review
- Comparison of biological properties of umbilical cord-derived mesenchymal stem cells from early and late passages: immunomodulatory ability is enhanced in aged cells.Molecular medicine reports · 2015Article
- Contribution of the Local RAS to Hematopoietic Function: A Novel Therapeutic Target.Frontiers in endocrinology · 2013Review
- Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment.Journal of the American Society of Nephrology : JASN · 2013Article
- Renal pericytes: multifunctional cells of the kidneys.Pflugers Archiv : European journal of physiology · 2013Review
- Control of renin [corrected] gene expression.Pflugers Archiv : European journal of physiology · 2013Review
- Umbilical cord-derived mesenchymal stem cells retain immunomodulatory and anti-oxidative activities after neural induction.Neural regeneration research · 2012Article
- Recent advances involving the renin-angiotensin system.Experimental cell research · 2012Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Renin is a key enzyme for cardiovascular and renal homeostasis and is produced by highly specialized endocrine cells in the kidney, known as juxtaglomerular (JG) cells. The nature and origin of these cells remain as mysteries. Previously, we have shown that the nuclear hormone receptor liver X receptor-alpha (LXRalpha) is a major transcriptional regulator of the expression of renin, c-myc, and other genes involved with growth/differentiation. In this study we test the hypothesis that LXRalpha plays an important role not only in renin expression but also in renin-containing cell differentiation, specifically from the mesenchymal stem cell (MSC), which may be the origin of the JG cell. Indeed, our data demonstrated that LXRalpha activation by its ligands or cAMP stimulated renin gene expression in both murine and human MSCs. Furthermore, sustained cAMP stimulation of murine MSCs overexpressing LXRalpha led to their differentiation into JG-like cells expressing renin and alpha-smooth muscle actin. These MSC-derived JG-like cells contained renin in secretory granules and released active renin in response to cAMP. In conclusion, the activation of LXRalpha stimulates renin expression and induces MSCs differentiation into renin-secreting, JG-like cells. Our results suggest that the MSC may be the origin of the juxtaglomerular cell and provide insight into novel understanding of pathophysiology of the renin-angiotensin system.
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