ArticleApplied and environmental microbiology2010
Sequence analysis of Leuconostoc mesenteroides bacteriophage Phi1-A4 isolated from an industrial vegetable fermentation.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Development of the Efficient Electroporation Protocol forInternational journal of molecular sciences · 2025Article
- Functional Dissection of P1 Bacteriophage Holin-like Proteins Reveals the Biological Sense of P1 Lytic System Complexity.International journal of molecular sciences · 2022Article
- Article
- Viruses in fermented foods: are they good or bad? Two sides of the same coin.Food microbiology · 2021Review
- Potential for Bacteriophage Endolysins to Supplement or Replace Antibiotics in Food Production and Clinical Care.Antibiotics (Basel, Switzerland) · 2018Review
- GAMOLA2, a Comprehensive Software Package for the Annotation and Curation of Draft and Complete Microbial Genomes.Frontiers in microbiology · 2017Article
- Bacteriophages of leuconostoc, oenococcus, and weissella.Frontiers in microbiology · 2014Review
- Isolation and characterization of vB_ArS-ArV2 - first Arthrobacter sp. infecting bacteriophage with completely sequenced genome.PloS one · 2014Article
- Current taxonomy of phages infecting lactic acid bacteria.Frontiers in microbiology · 2014Review
- Characterization of the genome of the dairy Lactobacillus helveticus bacteriophage {Phi}AQ113.Applied and environmental microbiology · 2013Article
- Classification of lytic bacteriophages attacking dairy Leuconostoc starter strains.Applied and environmental microbiology · 2013Article
- Identification of the receptor-binding protein in lytic Leuconostoc pseudomesenteroides bacteriophages.Applied and environmental microbiology · 2013Article
- Bacteriophage ecology in a commercial cucumber fermentation.Applied and environmental microbiology · 2012Article
- Characterization of a Leuconostoc bacteriophage infecting flavor producers of cheese starter cultures.Applied and environmental microbiology · 2012Article
- Bacteriophages and dairy fermentations.Bacteriophage · 2012Article
- Tracing lifestyle adaptation in prokaryotic genomes.Frontiers in microbiology · 2012Article
- Metagenomic analysis of kimchi, a traditional Korean fermented food.Applied and environmental microbiology · 2011Article
- Genome sequence and characterization of the Tsukamurella bacteriophage TPA2.Applied and environmental microbiology · 2011Article
- Metagenomic analysis of the viral communities in fermented foods.Applied and environmental microbiology · 2011Article
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vegetable fermentations rely on the proper succession of a variety of lactic acid bacteria (LAB). Leuconostoc mesenteroides initiates fermentation. As fermentation proceeds, L. mesenteroides dies off and other LAB complete the fermentation. Phages infecting L. mesenteroides may significantly influence the die-off of L. mesenteroides. However, no L. mesenteroides phages have been previously genetically characterized. Knowledge of more phage genome sequences may provide new insights into phage genomics, phage evolution, and phage-host interactions. We have determined the complete genome sequence of L. mesenteroides phage Phi1-A4, isolated from an industrial sauerkraut fermentation. The phage possesses a linear, double-stranded DNA genome consisting of 29,508 bp with a G+C content of 36%. Fifty open reading frames (ORFs) were predicted. Putative functions were assigned to 26 ORFs (52%), including 5 ORFs of structural proteins. The phage genome was modularly organized, containing DNA replication, DNA-packaging, head and tail morphogenesis, cell lysis, and DNA regulation/modification modules. In silico analyses showed that Phi1-A4 is a unique lytic phage with a large-scale genome inversion ( approximately 30% of the genome). The genome inversion encompassed the lysis module, part of the structural protein module, and a cos site. The endolysin gene was flanked by two holin genes. The tail morphogenesis module was interspersed with cell lysis genes and other genes with unknown functions. The predicted amino acid sequences of the phage proteins showed little similarity to other phages, but functional analyses showed that Phi1-A4 clusters with several Lactococcus phages. To our knowledge, Phi1-A4 is the first genetically characterized L. mesenteroides phage.
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