ArticleJournal of bacteriology2010
Histidine kinase-mediated production and autoassembly of Porphyromonas gingivalis fimbriae.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Porphyromonas gingivalis produces a functional HemH ferrochelatase important for its survival in a heme-limited environment.Scientific reports · 2026Article
- Article
- Inhibition of BTK and SYK attenuatesJournal of oral microbiology · 2025Article
- Identification of Critical Amino Acid Residues of a Two-Component Sensor Protein for Signal Sensing inPathogens (Basel, Switzerland) · 2024Article
- A pleiotropic role of sialidase in the pathogenicity ofInfection and immunity · 2024Article
- Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis.Journal of oral microbiology · 2024Article
- TLR2 Activation byFrontiers in immunology · 2022Article
- Insertional Inactivation ofMicroorganisms · 2021Article
- Research progress on two-component signal transduction systems inHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Review
- Phylogenetic diversity inJournal of oral microbiology · 2020Article
- Roles of Porphyromonas gingivalis and its virulence factors in periodontitis.Advances in protein chemistry and structural biology · 2020Review
- Activity of Streptococcus mutans VicR Is Modulated by Antisense RNA.Journal of dental research · 2018Article
- Two-component signal transduction systems in oral bacteria.Journal of oral microbiology · 2017Review
- Genes Contributing toFrontiers in cellular and infection microbiology · 2017Article
- Porphyromonas gingivalis initiates a mesenchymal-like transition through ZEB1 in gingival epithelial cells.Cellular microbiology · 2016Article
- A two-component system regulates gene expression of the type IX secretion component proteins via an ECF sigma factor.Scientific reports · 2016Article
- Noncanonical activation of β-catenin by Porphyromonas gingivalis.Infection and immunity · 2015Article
- Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis.MicrobiologyOpen · 2015Article
- Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.PloS one · 2014Article
- VimA mediates multiple functions that control virulence in Porphyromonas gingivalis.Molecular oral microbiology · 2013Review
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Authors and funding
2 authors.
Funding
Abstract
Porphyromonas gingivalis, a Gram-negative oral anaerobe, is strongly associated with chronic adult periodontitis, and it utilizes FimA fimbriae to persistently colonize and evade host defenses in the periodontal crevice. The FimA-related gene cluster (the fim gene cluster) is positively regulated by the FimS-FimR two-component system. In this study, comparative analyses between fimbriate type strain ATCC 33277 and fimbria-deficient strain W83 revealed differences in their fimS loci, which encode FimS histidine kinase. Using a reciprocal gene exchange system, we established that FimS from W83 is malfunctional. Complementation analysis with chimeric fimS constructs revealed that W83 FimS has a defective kinase domain due to a truncated conserved G3 box motif that provides an ATP-binding pocket. The introduction of the functional fimS from 33277 restored the production, but not polymerization, of endogenous FimA subunits in W83. Further analyses with a fimA-exchanged W83 isogenic strain showed that even the fimbria-deficient W83 retains the ability to polymerize FimA from 33277, indicating the assembly of mature FimA by a primary structure-dependent mechanism. It also was shown that the substantial expression of 33277-type FimA fimbriae in the W83 derivative requires the introduction and expression of the functional 33277 fimS. These findings indicate that FimSR is the unique and universal regulatory system that activates the fim gene cluster in a fimA genotype-independent manner.
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