ArticleMolecular biology and evolution2010
Haplotype structure and divergence at human and chimpanzee serotonin transporter and receptor genes: implications for behavioral disorder association analyses.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Evolution of threat response-related polymorphisms at theBiology letters · 2024Article
- Predicting anxiety-related personality traits by means of serotonergic VNTR variants STin2 and 5-HTTLPR.Journal of mood and anxiety disorders · 2023Article
- Article
- Population genetic variation ofJournal of genetics · 2021Article
- THE EXPOSOME IN HUMAN EVOLUTION: FROM DUST TO DIESEL.The Quarterly review of biology · 2019Article
- Serotonin Receptor 1A Variation Is Associated with Anxiety and Agonistic Behavior in Chimpanzees.Molecular biology and evolution · 2019Article
- Insights into the genetic foundation of aggression in Papio and the evolution of two length-polymorphisms in the promoter regions of serotonin-related genes (5-HTTLPR and MAOALPR) in Papionini.BMC evolutionary biology · 2016Article
- Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture.Biology letters · 2016Article
- Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes.Development and psychopathology · 2016Article
- Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review.Frontiers in psychology · 2016Review
- Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility.Development and psychopathology · 2015Article
- Patterns of genetic variation and the role of selection in HTR1A and HTR1B in macaques (Macaca).BMC genetics · 2014Article
- Development of Ego-Resiliency: Relations to Observed Parenting and Polymorphisms in the Serotonin Transporter Gene During Early Childhood.Social development (Oxford, England) · 2014Article
- The evolutionary history of SLC6A4 and the role of plasticity in Macaca.American journal of physical anthropology · 2014Article
- Identification of ethnically specific genetic variations in pan-asian ethnos.Genomics & informatics · 2014Article
- Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A trans-specific polymorphism in ZC3HAV1 is maintained by long-standing balancing selection and may confer susceptibility to multiple sclerosis.Molecular biology and evolution · 2012Article
- Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance.Developmental psychology · 2012Article
- Eye-tracking with nonhuman primates is now more accessible than ever before.American journal of primatology · 2011Article
- Searching for ancient balanced polymorphisms shared between Neanderthals and Modern Humans.Genetics and molecular biologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Genetic variation in the human serotonin system has long-been studied because of its functional consequences and links to various behavior-related disorders and it being routinely targeted in research and development for drug therapy. However, aside from clinical studies, little is known about this genetic diversity and how it differs within and between human populations with respect to haplotype structure, which can greatly impact phenotype association studies. In addition, no evolutionary approach among humans and other primates has examined how long- and short-term selective pressures explain existing serotonin variation. Here, we examine DNA sequence variation in natural population samples of 192 human and 40 chimpanzee chromosome sequences for the most commonly implicated approximately 38-kb serotonin transporter (SLC6A4) and approximately 63-kb serotonin 2A receptor (HTR2A) genes. Our comparative population genetic analyses find significant linkage disequilibrium associated with functionally relevant variants in humans, as well as geographic variation for these haplotypes, at both loci. In addition, although amino acid divergence is consistent with purifying selection, promoter and untranslated regions exhibit significantly high divergence in both species lineages. These evolutionary analyses imply that the serotonin system may have accumulated significant regulatory variation over both recent and ancient periods of time in both humans and chimpanzees. We discuss the implications of this variation for disease association studies and for the evolution of behavior-related phenotypes during the divergence of humans and our closest primate relatives.
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