ArticleRespiratory physiology & neurobiology2010
High CO2/H+ dialysis in the caudal ventrolateral medulla (Loeschcke's area) increases ventilation in wakefulness.
Article in Respiratory physiology & neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Molecular Organization of Autonomic, Respiratory, and Spinally-Projecting Neurons in the Mouse Ventrolateral Medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.Pflugers Archiv : European journal of physiology · 2020Article
- Hypercapnia-induced active expiration increases in sleep and enhances ventilation in unanaesthetized rats.The Journal of physiology · 2018Article
- Dorsal Raphe Serotonin Neurons Mediate COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Assessing Panic: Bridging the Gap Between Fundamental Mechanisms and Daily Life Experience.Frontiers in neuroscience · 2018Review
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
- Chemoreception and asphyxia-induced arousal.Respiratory physiology & neurobiology · 2013Review
- Focal microdialysis of CO₂ in the perifornical-hypothalamic area increases ventilation during wakefulness but not NREM sleep.Respiratory physiology & neurobiology · 2013Article
- Central chemoreceptors: locations and functions.Comprehensive Physiology · 2012Review
- Respiration and autonomic regulation and orexin.Progress in brain research · 2012Review
- Ventilatory effects of substance P-saporin lesions in the nucleus tractus solitarii of chronically hypoxic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Julius H. Comroe, Jr., distinguished lecture: central chemoreception: then ... and now.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- State-dependent central chemoreception: a role of orexin.Respiratory physiology & neurobiology · 2010Review
- Central respiratory chemoreception.The Journal of comparative neurology · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Central chemoreception, the detection of CO(2)/H(+) within the brain and the resultant effect on ventilation, was initially localized at two areas on the ventrolateral medulla, one rostral (rVLM-Mitchell's) the other caudal (cVLM-Loeschcke's), by surface application of acidic solutions in anesthetized animals. Focal dialysis of a high CO(2)/H(+) artificial cerebrospinal fluid (aCSF) that produced a milder local pH change in unanesthetized rats (like that with a approximately 6.6mm Hg increase in arterial P(CO2)) delineated putative chemoreceptor regions for the rVLM at the retrotrapezoid nucleus and the rostral medullary raphe that function predominantly in wakefulness and sleep, respectively. Here we ask if chemoreception in the cVLM can be detected by mild focal stimulation and if it functions in a state dependent manner. At responsive sites just beneath Loeschcke's area, ventilation was increased by, on average, 17% (P<0.01) only in wakefulness. These data support our hypothesis that central chemoreception is a distributed property with some sites functioning in a state dependent manner.
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