ArticleNeuroImage2010
Genetics of microstructure of cerebral white matter using diffusion tensor imaging.
Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 6 of them syntheses that pooled it.
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Who cites it
101 citing papers in PubMed, 6 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- White matter microstructure in relatives of people with schizophrenia or bipolar disorder: an ENIGMA meta-analysis.Molecular psychiatry · 2026Pooled it
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease.BMC medical genomics · 2022Pooled it
- The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis.Journal of affective disorders · 2022Pooled it
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Pooled it
- Article
- Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory.Scientific reports · 2025Article
- Neurogenetics of Brain Connectivity: Current Approaches to the Study (Review).Sovremennye tekhnologii v meditsine · 2024Review
- Diffusion tensor-based analysis of white matter in dogs with idiopathic epilepsy.Frontiers in veterinary science · 2023Article
- The inferior frontal gyrus and familial risk for bipolar disorder.Psychoradiology · 2022Review
- Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates.NeuroImage · 2022Article
- The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.Human brain mapping · 2022Article
- Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure.Brain structure & function · 2022Article
- Genetic Influence Underlying Brain Connectivity Phenotype: A Study on Two Age-Specific Cohorts.Frontiers in genetics · 2021Article
- Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.Molecular psychiatry · 2020Article
- Cingulum and abnormal psychological stress response in schizophrenia.Brain imaging and behavior · 2020Article
- Evidence for genetic correlation between human cerebral white matter microstructure and inflammation.Human brain mapping · 2019Article
- White matter integrity in medication-free women with peripartum depression: a tract-based spatial statistics study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Genetic relatedness of axial and radial diffusivity indices of cerebral white matter microstructure in late middle age.Human brain mapping · 2018Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
We analyzed the degree of genetic control over intersubject variability in the microstructure of cerebral white matter (WM) using diffusion tensor imaging (DTI). We performed heritability, genetic correlation and quantitative trait loci (QTL) analyses for the whole-brain and 10 major cerebral WM tracts. Average measurements for fractional anisotropy (FA), radial (L( perpendicular)) and axial (L( vertical line)) diffusivities served as quantitative traits. These analyses were done in 467 healthy individuals (182 males/285 females; average age 47.9+/-13.5 years; age range: 19-85 years), recruited from randomly-ascertained pedigrees of extended families. Significant heritability was observed for FA (h(2)=0.52+/-0.11; p=10(-7)) and L( perpendicular) (h(2)=0.37+/-0.14; p=0.001), while L( vertical line) measurements were not significantly heritable (h(2)=0.09+/-0.12; p=0.20). Genetic correlation analysis indicated that the FA and L( perpendicular) shared 46% of the genetic variance. Tract-wise analysis revealed a regionally diverse pattern of genetic control, which was unrelated to ontogenic factors, such as tract-wise age-of-peak FA values and rates of age-related change in FA. QTL analysis indicated linkages for whole-brain average FA (LOD=2.36) at the marker D15S816 on chromosome 15q25, and for L( perpendicular) (LOD=2.24) near the marker D3S1754 on the chromosome 3q27. These sites have been reported to have significant co-inheritance with two psychiatric disorders (major depression and obsessive-compulsive disorder) in which patients show characteristic alterations in cerebral WM. Our findings suggest that the microstructure of cerebral white matter is under a strong genetic control and further studies in healthy as well as patients with brain-related illnesses are imperative to identify the genes that may influence cerebral white matter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.