ArticleProgress in neuro-psychopharmacology & biological psychiatry2010
Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Accelerated brain aging associated with executive deficits in adolescence and early adulthood among individuals with schizophrenia and genetic high risk.BMC psychiatry · 2026Article
- Differences in Real-world Functioning Between Adoptees With High or Low Risk for Schizophrenia Spectrum Disorders-The Finnish Adoptive Family Study of Schizophrenia.Schizophrenia bulletin open · 2025Article
- The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11: the Danish high risk and resilience study.European child & adolescent psychiatry · 2024Article
- Executive functions in 7-year-old children of parents with schizophrenia or bipolar disorder compared with controls: The Danish High Risk and Resilience Study-VIA 7, a population-based cohort study.European child & adolescent psychiatry · 2021Article
- Clinical psychopathology in youth at familial high risk for psychosis.Early intervention in psychiatry · 2019Article
- Variability of ecological executive function in children and adolescents genetically at high risk for schizophrenia: a latent class analysis.European child & adolescent psychiatry · 2019Article
- Rethinking schizophrenia in the context of normal neurodevelopment.Frontiers in cellular neuroscience · 2013Article
- Early prodromal symptoms can predict future psychosis in familial high-risk youth.Journal of psychiatric research · 2012Article
- Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood.Molecular psychiatry · 2011Article
- Early and broadly defined psychosis risk mental states.Schizophrenia research · 2011Article
- Neurocognitive Functioning in Schizophrenia, their Unaffected Siblings and Healthy Controls: A Comparison.Indian journal of psychological medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Genetic diathesis to schizophrenia may involve alterations of adolescent neurodevelopment manifesting as cognitive deficits. Brain regions mediating executive function (fronto-striatal circuits) develop during adolescence while those supporting elementary aspects of attention (e.g. sustained focused attention) have a more protracted maturation beginning in childhood. We hence predicted that adolescents at risk for schizophrenia would show a failure of normal maturation of executive function. We prospectively assessed 18 offspring and 6 siblings of schizophrenia patients (HR) and 28 healthy controls at baseline, year-1 and year-2 follow-up using the Continuous Performance Test [visual-d'] and Wisconsin Card Sort Test (WCST). Perseverative errors on the WCST in HR remained stable but decreased in controls over the follow-up (study-group by assessment-time interaction, p=0.01, controlling for IQ). No significant study-group by assessment-time interactions were seen for sustained attentional performance. HR may not improve while healthy subjects progressively improve on executive function during adolescence and early adulthood. Our results suggest an altered maturational trajectory of executive function during adolescence in individuals at familial risk for schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.