ArticleSurgery2010
Postoperative Clostridium difficile-associated diarrhea.
Article in Surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Exocrine Pancreatic Insufficiency After Pancreatectomy for Malignancy: Systematic Review and Optimal Management Recommendations.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Pooled it
- Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis.World journal of gastroenterology · 2017Pooled it
- Clinical predictors of enzyme immunoassay accuracy in Clostridioides difficile infection: the impact of immune status and infection predisposing factors.BMC infectious diseases · 2026Article
- Incidence and clinical relevance of postoperative diarrhea after minimally invasive gastrectomy for gastric cancer: a single institution retrospective study of 1476 patients.Langenbeck's archives of surgery · 2023Article
- Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery-A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- Clinical characteristics and factors related to antibiotic-associated diarrhea in elderly patients with pneumonia: a retrospective cohort study.BMC geriatrics · 2021Article
- A nationwide assessment of the burden of healthcare-associated infections and antimicrobial use among surgical patients: results from Serbian point prevalence survey, 2017.Antimicrobial resistance and infection control · 2021Article
- Healthcare associatedThe Libyan journal of medicine · 2020Article
- Stress Ulcer Prophylaxis in Neurocritical Care.Neurocritical care · 2018Review
- The Impact of Bariatric Surgery on Short Term Risk of Clostridium Difficile Admissions.Obesity surgery · 2018Article
- The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- The Morbidity and Mortality of Laparoscopic Appendectomy in Patients with Cirrhosis.Clinical medicine insights. Gastroenterology · 2018Article
- The role of single-shot metronidazole in the prevention of Clostridium difficile infection following ileostomy reversal surgery.International journal of colorectal disease · 2017Article
- Antibiotic prophylaxis for surgical site infections as a risk factor for infection with Clostridium difficile.PloS one · 2017Article
- Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach.BMC infectious diseases · 2016Article
- Postoperative burden of hospital-acquired Clostridium difficile infection.Infection control and hospital epidemiology · 2015Article
- The simple predictors of pseudomembranous colitis in patients with hospital-acquired diarrhea: a prospective observational study.Gut and liver · 2014Observational
- Excess risk of Clostridium difficile infection in ovarian cancer is related to exposure to broad-spectrum antibiotics.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- [Newly recognized side-effects of proton pump inhibitors. Arguments in favour of fundoplication for GERD?].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Review
- Very mild dementia and medical comorbidity independently predict health care use in the elderly.Journal of primary care & community health · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAbdominal surgery is thought to be a risk factor for Clostridium difficile-associated diarrhea (CDAD). The aims of this study were to discern pre-operative factors associated with postoperative CDAD, examine outcomes after postoperative CDAD, and compare outcomes of postoperative versus medical CDAD.
methodsData from 3904 patients who had abdominal operations at Montefiore Medical Center were extracted from Montefiore's clinical information system. Cases of 30-day postoperative CDAD were identified. Pre-operative factors associated with developing postoperative CDAD were identified using logistic regression. Medical patients and surgical patients with postoperative CDAD were compared for demographic and clinical characteristics, CDAD recurrence, and 90-day postinfection mortality.
resultsThe rate of 30-day postoperative CDAD was 1.2%. After adjustment for age and comorbidities, factors significantly associated with postoperative CDAD were: antibiotic use (OR: 1.94), proton pump inhibitor (PPI) use (OR: 2.32), prior hospitalization (OR: 2.27), and low serum albumin (OR: 2.05). In comparison with medical patients with CDAD, postoperative patients with CDAD were significantly more likely to have received antibiotics (98% vs 85%), less likely to have received a PPI (39% vs 58%), or to have had a prior hospitalization (43% vs 67%). Postoperative patients with CDAD had decreased risk of mortality when compared with medical patients with CDAD (HR 0.36).
conclusionCDAD is an infrequent complication after abdominal operations. Several avoidable pre-operative exposures (eg, antibiotic and PPI use) were identified that increase the risk of postoperative CDAD. Postoperative CDAD is associated with decreased risk of mortality when compared with CDAD on the medical service.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.